从中年到晚年的静息 EEG 功率谱：与年龄、认知、APOE-ɛ4 携带、以及心血管代谢负担的关联。
Resting EEG power spectra across middle to late life: associations with age, cognition, APOE-ɛ4 carriage, and cardiometabolic burden.
机构信息
Alliance for Research in Exercise, Nutrition and Activity, Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.
Alliance for Research in Exercise, Nutrition and Activity, Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia; Medical Radiation Science, Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.
出版信息
Neurobiol Aging. 2023 Oct;130:93-102. doi: 10.1016/j.neurobiolaging.2023.06.004. Epub 2023 Jun 8.
We investigated how resting electroencephalography (EEG) measures are associated with risk factors for late-life cognitive impairment and dementia, including age, apolipoprotein E ɛ4 (APOE-ɛ4) carriage, and cardiometabolic burden. Resting EEG was recorded from 86 adults (50-80 years of age). Participants additionally completed the Addenbrooke's Cognitive Examination (ACE) III and had blood drawn to assess APOE-ɛ4 carriage status and cardiometabolic burden. EEG power spectra were decomposed into sources of periodic and aperiodic activity to derive measures of aperiodic component slope and alpha (7-14 Hz) and beta (15-30 Hz) peak power and peak frequency. Alpha and beta peak power measures were corrected for aperiodic activity. The aperiodic component slope was correlated with ACE-III scores but not age. Alpha peak frequency decreased with age. Individuals with higher cardiometabolic burden had lower alpha peak frequencies and lower beta peak power. APOE-ɛ4 carriers had lower beta peak frequencies. Our findings suggest that the slope of the aperiodic component of resting EEG power spectra is more closely associated with measures of cognitive performance rather than chronological age in older adults.
我们研究了静息脑电图（EEG）测量值与老年认知障碍和痴呆的风险因素（包括年龄、载脂蛋白 E ɛ4（APOE-ɛ4）携带情况和心脏代谢负担）之间的关系。从 86 名成年人（50-80 岁）中记录了静息 EEG。参与者还完成了 Addenbrooke's 认知评估（ACE）III 测试，并抽取血液以评估 APOE-ɛ4 携带状态和心脏代谢负担。将 EEG 功率谱分解为周期性和非周期性活动的来源，以得出非周期性成分斜率和 alpha（7-14 Hz）和 beta（15-30 Hz）的峰值功率和峰值频率的测量值。对非周期性活动进行了 alpha 和 beta 峰值功率测量的校正。非周期性成分斜率与 ACE-III 评分相关，但与年龄无关。alpha 峰值频率随年龄增长而降低。心脏代谢负担较高的个体 alpha 峰值频率较低，beta 峰值功率较低。APOE-ɛ4 携带者的 beta 峰值频率较低。我们的研究结果表明，静息脑电图功率谱的非周期性成分斜率与老年人的认知表现测量值更密切相关，而不是与实际年龄相关。
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