School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria VIC3001, Australia.
Department of Endocrinology & Metabolism, Lancashire Teaching Hospitals, NHS Trust & Manchester Metropolitan University, Preston, PR2 9HT, UK.
Endocrinol Metab Clin North Am. 2023 Sep;52(3):xv-xvi. doi: 10.1016/j.ecl.2023.03.001. Epub 2023 Mar 22.
The pathobiology of MAFLD is such a big puzzle, and many of the metabolic and other health consequences of the disease are not yet fully elucidated. In their review on "Pathobiology of metabolic-associated fatty liver disease," Fouda and colleagues update the current evidence on the disease characteristics. The prevalence of MAFLD has reached epidemic proportions in children and young adults in the recent years, with figures reaching as high as 15% owing to the global obesity pandemic. Vespoli and colleagues in their review "MAFLD in childhood and adolescence" portray the latest updates and new emerging therapies for pediatric MAFLD. Gofton and colleagues update the association between metabolically unhealthy visceral adiposity and MAFLD in individuals with "normal body weight" in their review "Lean MAFLD." The pathobiological link between dyslipidemia and MAFLD is elaborated by Anwar and colleagues with the therapeutic algorithms. Ren and colleagues summarize evidence surrounding cardiovascular disease and MAFLD and analyze management strategies focusing on prevention of cardiovascular disease in MAFLD. Another important review by Kapoor and Kalra discusses the hot topic of diabetes and MAFLD and portrays the latest management strategies for both diseases. Barber and colleagues thoroughly review the gut-liver axis in the context of gut dysbiosis in MAFLD. Sarcopenia and MAFLD is the theme of the review by Bali and colleagues. This article emphasizes the importance of early identification of sarcopenia in patients with MAFLD and vice versa. Obstructive sleep apnea and MAFLD are often underdiagnosed and inadequately managed. Preshy and Brown in their review highlight the association between these common disorders to enhance the global awareness with updated evaluation and management strategies in their review. Mandato and colleagues review current literature on pregnancy and MAFLD and update the best clinical approach in their article. The interlink between polycystic ovary syndrome and MAFLD, their coexistence, diagnosis, and current management strategies are critically apprised by Vidal-Cevallos and colleagues in their review. Venkatesan and Haroon successively provide more important evidence for the clinical management of MAFLD with additional focus on minority groups and currently available therapies.
代谢相关性脂肪性肝病的发病机制非常复杂，其许多代谢及其他健康后果尚未完全阐明。在他们题为“代谢相关性脂肪性肝病的发病机制”的综述中，Fouda 及其同事更新了有关该疾病特征的最新证据。近年来，由于全球肥胖流行，儿童和青少年代谢相关性脂肪性肝病的患病率已达到流行程度，高达 15%。Vespoli 及其同事在他们的综述“儿童和青少年代谢相关性脂肪性肝病”中描绘了儿科代谢相关性脂肪性肝病的最新更新和新出现的治疗方法。Gofton 及其同事在他们的综述“正常体重个体的代谢不健全内脏型肥胖与代谢相关性脂肪性肝病”中更新了代谢不健全内脏型肥胖与代谢相关性脂肪性肝病的关联。Anwar 及其同事详细阐述了血脂异常与代谢相关性脂肪性肝病之间的病理生物学联系，并制定了治疗算法。Ren 及其同事围绕心血管疾病与代谢相关性脂肪性肝病的关系进行了总结，并分析了重点关注代谢相关性脂肪性肝病心血管疾病预防的管理策略。Kapoor 和 Kalra 的另一篇重要综述讨论了糖尿病与代谢相关性脂肪性肝病这一热门话题，并描绘了这两种疾病的最新管理策略。Barber 及其同事在代谢相关性脂肪性肝病肠道菌群失调的背景下彻底综述了肠道-肝脏轴。Bali 及其同事的综述主题是肌肉减少症与代谢相关性脂肪性肝病，强调了在代谢相关性脂肪性肝病患者中早期识别肌肉减少症的重要性，反之亦然。阻塞性睡眠呼吸暂停与代谢相关性脂肪性肝病常被漏诊且处理不当。在他们的综述中，Preshy 和 Brown 强调了这两种常见疾病之间的关联，以提高对这些疾病的全球认识，并更新了评估和管理策略。Mandato 及其同事综述了目前关于妊娠与代谢相关性脂肪性肝病的文献，并在他们的文章中更新了最佳临床方法。Vidal-Cevallos 及其同事批判性地评估了多囊卵巢综合征与代谢相关性脂肪性肝病之间的相互关系、它们的共存、诊断和当前管理策略。Venkatesan 和 Haroon 连续提供了更多关于代谢相关性脂肪性肝病临床管理的重要证据，重点关注少数族裔群体和目前可用的治疗方法。
