Unit on the Neurobiology of Affective Memory, National Institute of Mental Health, Bethesda, MD, USA.
Department of Psychological & Brain Sciences, Institute for Neuroscience, Texas A&M University, College Station, TX, USA.
Trends Neurosci. 2023 Sep;46(9):701-711. doi: 10.1016/j.tins.2023.06.006. Epub 2023 Jul 24.
Plasticity elicited by fear conditioning (FC) is thought to support the storage of aversive associative memories. Although work over the past decade has revealed FC-induced plasticity beyond canonical sites in the basolateral complex of the amygdala (BLA), it is not known whether modifications across distributed circuits make equivalent or distinct contributions to aversive memory. Here, we review evidence demonstrating that experience-dependent synaptic plasticity in the central nucleus of the amygdala (CeA) has a circumscribed role in memory expression per se, guiding the selection of defensive programs in response to acquired threats. We argue that the CeA may be a key example of a broader phenomenon by which synaptic plasticity at specific nodes of a distributed network makes a complementary contribution to distinct memory processes.
恐惧条件反射（FC）引起的可塑性被认为支持了厌恶联想记忆的存储。尽管在过去的十年中，工作已经揭示了除了杏仁核基底外侧复合体（BLA）之外的经典部位之外的 FC 诱导的可塑性，但尚不清楚分布式电路中的修饰是否对厌恶记忆有同等或不同的贡献。在这里，我们回顾了证明杏仁核中央核（CeA）中经验依赖性突触可塑性本身对记忆表达具有限定作用的证据，指导了针对获得的威胁选择防御程序。我们认为，CeA 可能是一个更广泛现象的一个关键例子，即在分布式网络的特定节点处的突触可塑性对不同的记忆过程做出了补充贡献。
