限制-修饰系统调控鲍曼不动杆菌的转化。
Restriction-methylation systems regulate transformation in Acinetobacter baumannii.
机构信息
Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo A. Ugalde', IIB-IIBIO, Universidad Nacional de San Martín-CONICET, San Martín, Buenos Aires, Argentina.
出版信息
Trends Microbiol. 2023 Sep;31(9):879-881. doi: 10.1016/j.tim.2023.07.009. Epub 2023 Jul 24.
Antimicrobial resistance in Acinetobacter baumannii is a major concern. Natural transformation remains understudied as a horizontal gene transfer (HGT) mechanism for the spread of resistance genes. Recent work (Vesel et al.) reveals a profound impact of the state of donor DNA methylation with strong implications for HGT of resistance determinants in this worrisome pathogen.
鲍曼不动杆菌的耐药性是一个主要关注点。自然转化作为一种水平基因转移（HGT）机制，对于耐药基因的传播，其研究还不够充分。最近的研究（Vesel 等人）揭示了供体 DNA 甲基化状态的深远影响，这对该令人担忧的病原体中耐药决定因素的 HGT 具有重要意义。
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