粘连性小肠梗阻手术干预的预测因素和非手术治疗的理想时间。

Predictive factors for operative intervention and ideal length of non-operative trial in adhesive small bowel obstruction.

机构信息

Department of Surgery, Inova Fairfax Medical Campus, 3300 Gallows Road, Falls Church, VA, 22042, USA.

University of Virginia School of Medicine, Charlottesville, USA.

出版信息

Surg Endosc. 2023 Nov;37(11):8628-8635. doi: 10.1007/s00464-023-10282-9. Epub 2023 Jul 26.

Abstract

BACKGROUND

Small bowel obstruction (SBO) is responsible for 350,000 U.S. hospitalizations and costs ~ $2.3 billion annually. The current standard of care for SBO is to trial 3 to 5 days of non-operative management. This study evaluated the factors associated with operative management.

METHODS

This retrospective cohort study included adult patients admitted with adhesive SBO. Exclusions were for operative intervention within 24 h or death.

RESULTS

At baseline (N = 360), mean age was 65.9 years, 57.8% female, 72.3% white, mean BMI 26.1, 38.7% with history of SBO and 98.1% had history of abdominal surgery. Symptom onset prior to hospitalization was 1-2 days. 55.6% had successful non-operative management at discharge (median length of stay 3 days) vs. 44.4% operative conversion. In univariate analyses, BMI, SBO history, surgical history, days symptom onset, vitals, abdominal pain, obstipation, acute kidney injury, and lack of small bowel feces sign on CT scan were significantly associated with operative management. In a multivariable logistic regression, after controlling all other variables, a lack of small bowel feces sign (adjusted odds ratio, aOR = 2.25, 95% CI 1.06-4.77, p = 0.04) and history of exploratory laparotomy (aOR = 0.44, 95% CI 0.21-0.90, p = 0.03) were significantly associated with operative management. Time from admission to surgery averaged 3.89 days: small bowel resection (55/160) was 4.9 days (median = 4), compared to patients without resection (3.4 days, median = 2; p = 0.00; OR = 1.2, 95% CI 1.07-1.35).

CONCLUSIONS

A lack of small bowel feces sign can be a potential indicator for operative management and should be further explored. Since the median resolution of symptoms in the non-operative management group was ~ 2 days and a 20% higher odds for bowel resection each day surgery is delayed, the conservative trial period for adhesive SBO should not exceed 3 days.

摘要

背景

小肠梗阻(SBO)导致美国每年有 35 万人住院,医疗费用达 23 亿美元。目前 SBO 的标准治疗方法是尝试非手术治疗 3 至 5 天。本研究评估了与手术治疗相关的因素。

方法

本回顾性队列研究纳入了因粘连性 SBO 住院的成年患者。排除标准为 24 小时内进行手术干预或死亡。

结果

在基线(N=360)时,患者平均年龄为 65.9 岁,57.8%为女性,72.3%为白人,平均 BMI 为 26.1,38.7%有 SBO 病史,98.1%有腹部手术史。症状发作前住院时间为 1-2 天。55.6%的患者在出院时成功接受了非手术治疗(中位住院时间为 3 天),而 44.4%的患者需要转为手术治疗。单因素分析显示,BMI、SBO 病史、手术史、症状发作天数、生命体征、腹痛、便秘、急性肾损伤和 CT 扫描未见小肠粪便征与手术治疗显著相关。多变量逻辑回归分析显示,在校正所有其他变量后,未见小肠粪便征(校正优势比,aOR=2.25,95%CI 1.06-4.77,p=0.04)和剖腹探查术史(aOR=0.44,95%CI 0.21-0.90,p=0.03)与手术治疗显著相关。从入院到手术的平均时间为 3.89 天:小肠切除术(55/160)为 4.9 天(中位数=4),而未行切除术的患者为 3.4 天(中位数=2;p=0.00;OR=1.2,95%CI 1.07-1.35)。

结论

未见小肠粪便征可能是手术治疗的潜在指标,应进一步探讨。由于非手术治疗组症状缓解的中位数时间约为 2 天,且每天延迟手术的肠道切除风险增加 20%,粘连性 SBO 的保守治疗期不应超过 3 天。

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