Etling N, Fouque F, Garabedian M
Reprod Nutr Dev (1980). 1986;26(3):841-7.
To determine if calcium had a goitrogenic effect on the thyroid function in rats, weanling rats were fed, for three weeks, a diet containing either 0.5 microgram or 0.04 microgram iodine per gram of diet, or an adequate (0.47%) or an excessive (2%) amount of calcium. With an adequate iodine diet, the calcium load did not induce an increase in the weight of the thyroid or a decrease in serum thyroid hormone concentration. However, the rats given a calcium load had a lighter body weight and a lower iodine content in the thyroid tissue; they also had a higher thyroxine (T4) content in the liver and kidney tissues than the rats receiving an adequate calcium diet. With a low iodine diet, the calcium load brought out a decrease in growth and a lower serum triiodothyronine (T3) concentration and liver and kidney T3 contents. These changes suggest that the calcium load might have acted on the thyroid function through an inhibition of T4-T3 conversion in the serum as well as in liver and kidney tissues.
为确定钙是否对大鼠甲状腺功能有致甲状腺肿作用，将断乳大鼠用每克饲料含0.5微克或0.04微克碘的饲料、适量（0.47%）或过量（2%）的钙喂养三周。在饲料碘含量充足时，钙负荷并未导致甲状腺重量增加或血清甲状腺激素浓度降低。然而，给予钙负荷的大鼠体重较轻，甲状腺组织中的碘含量较低；与摄入适量钙饲料的大鼠相比，它们肝脏和肾脏组织中的甲状腺素（T4）含量也更高。在低碘饲料喂养时，钙负荷导致生长减缓、血清三碘甲状腺原氨酸（T3）浓度降低以及肝脏和肾脏T3含量降低。这些变化表明，钙负荷可能通过抑制血清以及肝脏和肾脏组织中的T4-T3转化作用于甲状腺功能。
