Etling N, Levy M, Fouque F
INSERM U.30, Hôpital des Enfants-Malades, Paris.
Ann Endocrinol (Paris). 1987;48(6):452-6.
Thyroid hormones were determined in rat serum, thyroid, liver and kidney tissues; the animals were fed for 40 days an equilibrate diet and various amounts of lithium carbonate were added to drinks. Serum lithium levels were related to their absorption. There was no change in rats drinking 300 mg Li2CO3/l solution for 5 weeks or 600 mg/l for 2 weeks, when compared to control rats. But 600 mg/l solutions for 5 weeks led to hormone increase in thyroid tissue. With 1200 mg/l acute hormonal decrease was seen in serum (thyroxine, T4: 3.2 micrograms/dl and control: 4, triiodothyronine T3: 54.8 ng/dl and control: 64) in liver tissue T3: 2.6 ng/g and control: 3.5), and in kidney tissue (T3: 4.8 ng/g and control: 6.4). In some animals receiving 600 or 1200 mg, lithium concentration was very high, body weights were very much reduced and there was large hormonal decrease in serum (T4: 1.4 micrograms/dl, T3: 48.5 ng/dl) in liver tissue (T4: 10.5 ng/g and control: 20.7; T3: 2.1 ng/g) and in kidney tissue (T4: 6.9 ng/g and control: 13.5 and T3: 3.3 ng/g). Hormonal changes were parallel to tubular kidney damage. These results are similar to those described in patients receiving lithium treatment.
在大鼠血清、甲状腺、肝脏和肾脏组织中测定甲状腺激素；给动物喂食40天平衡饮食，并在饮水中添加不同量的碳酸锂。血清锂水平与它们的吸收有关。与对照大鼠相比，饮用300mg Li2CO3 / l溶液5周或600mg / l溶液2周的大鼠没有变化。但是饮用600mg / l溶液5周会导致甲状腺组织中激素增加。急性给予1200mg / l时，血清（甲状腺素，T4：3.2微克/分升，对照：4；三碘甲状腺原氨酸T3：54.8纳克/分升，对照：64）、肝脏组织（T3：2.6纳克/克，对照：3.5）和肾脏组织（T3：4.8纳克/克，对照：6.4）中出现激素减少。在一些接受600或1200mg的动物中，锂浓度非常高，体重显著减轻，血清（T4：1.4微克/分升，T3：48.5纳克/分升）、肝脏组织（T4：10.5纳克/克，对照：20.7；T3：2.1纳克/克）和肾脏组织（T4：6.9纳克/克，对照：13.5，T3：3.3纳克/克）中出现大量激素减少。激素变化与肾小管损伤平行。这些结果与接受锂治疗的患者中描述的结果相似。
