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甜叶菊糖苷是甜叶菊的甜味糖苷,它能抑制分离的灌注大鼠肝脏中苍术苷的作用。

Stevioside, the sweet glycoside of Stevia rebaudiana, inhibits the action of atractyloside in the isolated perfused rat liver.

作者信息

Ishii E L, Bracht A

出版信息

Res Commun Chem Pathol Pharmacol. 1986 Jul;53(1):79-91.

PMID:3749609
Abstract

Stevioside inhibits the action of atractyloside on energy metabolism in the isolated perfused rat liver. The effects of atractyloside on glycolysis, glycogenolysis, gluconeogenesis and oxygen uptake are decreased by stevioside. The concentration for half-maximal action is 0.5 mM. The site of the action is located on the outside of the cell. Possibly, stevioside affects the transport of atractyloside across the cell membrane.

摘要

甜菊糖苷可抑制苍术苷对离体灌注大鼠肝脏能量代谢的作用。甜菊糖苷可降低苍术苷对糖酵解、糖原分解、糖异生和氧摄取的影响。半数最大效应浓度为0.5 mM。作用位点位于细胞外。甜菊糖苷可能影响苍术苷跨细胞膜的转运。

相似文献

1
Stevioside, the sweet glycoside of Stevia rebaudiana, inhibits the action of atractyloside in the isolated perfused rat liver.甜叶菊糖苷是甜叶菊的甜味糖苷,它能抑制分离的灌注大鼠肝脏中苍术苷的作用。
Res Commun Chem Pathol Pharmacol. 1986 Jul;53(1):79-91.
2
Influence of stevioside on hepatic glycogen levels in fasted rats.甜菊糖苷对禁食大鼠肝糖原水平的影响。
Res Commun Chem Pathol Pharmacol. 1994 Apr;84(1):111-8.
3
Stevioside is not metabolized in the isolated perfused rat liver.甜菊糖苷在离体灌注的大鼠肝脏中不发生代谢。
Res Commun Mol Pathol Pharmacol. 1995 Feb;87(2):167-75.
4
Inhibition of monosaccharide transport in the intact rat liver by stevioside.甜菊糖苷对完整大鼠肝脏中糖类运输的抑制作用。
Biochem Pharmacol. 1987 May 1;36(9):1417-33. doi: 10.1016/0006-2952(87)90107-9.
5
Sensitivity of ketogenesis and citric acid cycle to stevioside inhibition of palmitate transport across the cell membrane.生酮作用和柠檬酸循环对甜菊糖苷抑制棕榈酸跨细胞膜转运的敏感性。
Braz J Med Biol Res. 1991;24(8):767-71.
6
Effect of stevioside on PAH transport by isolated perfused rabbit renal proximal tubule.甜菊糖苷对离体灌注兔肾近端小管PAH转运的影响。
Can J Physiol Pharmacol. 2000 Sep;78(9):737-44.
7
[Effect of guaraná and Stévia Rebaudiana Bertoni (leaves) extracts, and stevioside, on the fermentation and synthesis of extracellular insoluble polysaccharides of dental plaque].[瓜拉那和甜叶菊(叶)提取物以及甜菊糖苷对牙菌斑细胞外不溶性多糖发酵和合成的影响]
Rev Odontol Univ Sao Paulo. 1987 Oct-Dec;1(4):9-13.
8
Comparative effects of Stevia rebaudiana leaves and stevioside on glycaemia and hepatic gluconeogenesis.甜叶菊叶和甜菊糖苷对血糖及肝脏糖异生的比较作用
Planta Med. 2006 Jun;72(8):691-6. doi: 10.1055/s-2006-931586. Epub 2006 May 29.
9
[Study of physiological and toxic effects of a sweetening agent stevioside (review of the literature)].[甜味剂甜菊糖苷的生理及毒性作用研究(文献综述)]
Vopr Pitan. 2001;70(4):41-4.
10
Inhibitory effect of stevioside on calcium influx to produce antihypertension.甜菊糖苷对钙内流产生降压作用的抑制效果。
Planta Med. 2001 Dec;67(9):796-9. doi: 10.1055/s-2001-18841.

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1
Direct and indirect targets of carboxyatractyloside, including overlooked toxicity toward nucleoside diphosphate kinase (NDPK) and mitochondrial H leak.羧基荜茇酰胺的直接和间接靶点,包括对核苷二磷酸激酶(NDPK)和线粒体 H 渗漏的被忽视的毒性。
Pharm Biol. 2023 Dec;61(1):372-390. doi: 10.1080/13880209.2023.2168704.
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The action of extracellular NAD+ on gluconeogenesis in the perfused rat liver.细胞外烟酰胺腺嘌呤二核苷酸(NAD⁺)对灌注大鼠肝脏中糖异生的作用。
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