急性铝中毒：几种解毒疗法对小鼠疗效的研究

Acute aluminium intoxication: a study of the efficacy of several antidotal treatments in mice.

作者信息

Domingo J L, Llobet J M, Gómez M, Corbella J

出版信息

Res Commun Chem Pathol Pharmacol. 1986 Jul;53(1):93-104.

Abstract

The effect of the chelating agents deferoxamine mesylate (DFOA), sodium salicylate, citric acid, Na2Ca-ethylendiaminetetracetate (EDTA), nitrilotriacetic acid (NTA), L-cysteine, N-acetyl-L-cysteine (NAC) and 2, 3-dimercaptosuccinic acid (DMSA) on the lethality, elimination and tissue retention of aluminum was investigated on male Swiss mice. To determine the effect of the various chelators on the lethality of aluminium, various doses of Al (NO3)3.9H2O (3.0 - 7.5 mmol/kg) were given intraperitoneally followed immediately by the ip administration of the chelator (at dose equal to one-third of their respective LD50). Survival was recorded at the end of 14 days. Significant increases in survival were noted with citric acid and DFOA. A decrease of the aluminium concentration in various tissues, and an increase in urinary and fecal elimination of aluminium were also noted with citric acid, DFOA, and sodium salicylate. Citric acid appear to be the most effective agent of those tested in the prevention of acute aluminum intoxication.

摘要

研究了螯合剂甲磺酸去铁胺（DFOA）、水杨酸钠、柠檬酸、乙二胺四乙酸二钠钙（EDTA）、次氮基三乙酸（NTA）、L-半胱氨酸、N-乙酰-L-半胱氨酸（NAC）和2,3-二巯基丁二酸（DMSA）对雄性瑞士小鼠铝的致死率、清除率和组织潴留的影响。为了确定各种螯合剂对铝致死率的影响，腹腔注射不同剂量的Al(NO3)3·9H2O（3.0 - 7.5 mmol/kg），随后立即腹腔注射螯合剂（剂量等于各自LD50的三分之一）。在14天结束时记录存活率。观察到柠檬酸和DFOA可显著提高存活率。柠檬酸、DFOA和水杨酸钠还可使各种组织中的铝浓度降低，铝的尿排泄和粪排泄增加。在预防急性铝中毒方面，柠檬酸似乎是所测试的螯合剂中最有效的。