螯合剂作为急性硝酸镓中毒解毒剂的相对疗效。
Relative efficacy of chelating agents as antidotes for acute gallium nitrate intoxication.
作者信息
Domingo J L, Llobet J M, Corbella J
出版信息
Arch Toxicol. 1987 Feb;59(5):382-3. doi: 10.1007/BF00295095.
Twelve chelating agents were administered to mice by IP injection to compare their relative effectiveness in preventing death after a single IP injection of gallium nitrate. Na2Ca-ethylenediaminetetraacetate (EDTA), Na3Ca-diethylenetriaminepentaacetate (DTPA), dimercaptosuccinic acid (DMSA), 4,5-dihydroxy-1,3-benzene-disulfonic acid (Tiron), sodium diethyldithiocarbamate (DDC), L-cysteine and sodium salicylate were not effective for acute gallium nitrate intoxication. The therapeutic indices of the effective chelators were: 25.4 (deferoxamine mesylate), 35.7 (citric acid), 42.3 (succinic acid), 52.2 (malic acid) and 111.1 (oxalic acid).
通过腹腔注射给小鼠施用12种螯合剂，以比较它们在单次腹腔注射硝酸镓后预防死亡的相对有效性。乙二胺四乙酸二钠钙（EDTA）、二乙烯三胺五乙酸三钠钙（DTPA）、二巯基丁二酸（DMSA）、4,5-二羟基-1,3-苯二磺酸（钛铁试剂）、二乙基二硫代氨基甲酸钠（DDC）、L-半胱氨酸和水杨酸钠对急性硝酸镓中毒无效。有效螯合剂的治疗指数分别为：25.4（去铁胺甲磺酸盐）、35.7（柠檬酸）、42.3（琥珀酸）、52.2（苹果酸）和111.1（草酸）。
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