Domingo J L, Gómez M, Llobet J M, Corbella J
Laboratory of Toxicology and Biochemistry, School of Medicine, Reus, Spain.
Hum Toxicol. 1988 May;7(3):259-62. doi: 10.1177/096032718800700305.
The relative efficacy of citric, malic, malonic, oxalic and succinic acids, and deferoxamine mesylate (DFOA) on the toxicity, distribution and excretion in mice exposed to aluminum were compared. Chelating agents were administered intraperitoneally at a dose equal to one-fourth of their respective LD50. To determine the effect of the various chelators on the toxicity of aluminum, various doses of aluminum nitrate (938-3188 mg/kg) were administered intraperitoneally, followed by one of the chelators. Survival was recorded at the end of 14 days. Malic and succinic acids were the most effective. Malic acid and DFOA were the most effective in increasing the urinary excretion of aluminum. Citric acid was the most effective in increasing the faecal excretion of aluminum. Malonic, oxalic and succinic acids had no overall beneficial effects. Citric acid would appear to be the most effective agent of those tested in the prevention of acute aluminium intoxication. However, before the use of these compounds in human aluminium intoxication is possible, further investigations including the effects of these chelators after chronic aluminium intoxication are required.
比较了柠檬酸、苹果酸、丙二酸、草酸和琥珀酸以及甲磺酸去铁胺（DFOA）对暴露于铝的小鼠的毒性、分布和排泄的相对功效。螯合剂以等于其各自半数致死量四分之一的剂量腹腔注射。为了确定各种螯合剂对铝毒性的影响，腹腔注射不同剂量的硝酸铝（938 - 3188毫克/千克），随后注射其中一种螯合剂。在14天结束时记录存活情况。苹果酸和琥珀酸最为有效。苹果酸和DFOA在增加铝的尿排泄方面最为有效。柠檬酸在增加铝的粪便排泄方面最为有效。丙二酸、草酸和琥珀酸没有总体有益效果。在 tested的这些试剂中，柠檬酸似乎是预防急性铝中毒最有效的试剂。然而，在这些化合物用于人类铝中毒之前，需要进行进一步的研究，包括慢性铝中毒后这些螯合剂的影响。
