钙依地酸可恢复头孢他啶-阿维巴坦或氨曲南对产碳青霉烯酶感染的活性。
Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producing infections.
作者信息
Wannigama Dhammika Leshan, Sithu Shein Aye Mya, Hurst Cameron, Monk Peter N, Hongsing Parichart, Phattharapornjaroen Phatthranit, Fox Ditcham William Graham, Ounjai Puey, Saethang Thammakorn, Chantaravisoot Naphat, Wapeesittipan Pattama, Luk-In Sirirat, Sae-Joo Sasipen, Nilgate Sumanee, Rirerm Ubolrat, Tanasatitchai Chanikan, Kueakulpattana Naris, Laowansiri Matchima, Liao Tingting, Kupwiwat Rosalyn, Rojanathanes Rojrit, Ngamwongsatit Natharin, Tungsanga Somkanya, Leelahavanichkul Asada, Devanga Ragupathi Naveen Kumar, Badavath Vishnu Nayak, Hosseini Rad S M Ali, Kanjanabuch Talerngsak, Hirankarn Nattiya, Storer Robin James, Cui Longzhu, Amarasiri Mohan, Ishikawa Hitoshi, Higgins Paul G, Stick Stephen M, Kicic Anthony, Chatsuwan Tanittha, Abe Shuichi
机构信息
Department of Infectious Diseases and Infection Control, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
出版信息
iScience. 2023 Jun 28;26(7):107215. doi: 10.1016/j.isci.2023.107215. eCollection 2023 Jul 21.
Developing an effective therapy to overcome carbapenemase-positive (CPKp) is an important therapeutic challenge that must be addressed urgently. Here, we explored a Ca-EDTA combination with aztreonam or ceftazidime-avibactam and against diverse CPKp clinical isolates. The synergy testing of this study demonstrated that novel aztreonam-Ca-EDTA or ceftazidime-avibactam-Ca-EDTA combination was significantly effective in eliminating planktonic and mature biofilms , as well as eradicating CPKp infections . Both combinations revealed significant therapeutic efficacies in reducing bacterial load in internal organs and protecting treated mice from mortality. Conclusively, this is the first and study to demonstrate that novel aztreonam-Ca-EDTA or ceftazidime-avibactam-Ca-EDTA combinations provide favorable efficacy and safety for successful eradication of carbapenemase-producing planktonic and biofilm infections.
开发一种有效的疗法来克服碳青霉烯酶阳性（CPKp）是一项必须紧急应对的重要治疗挑战。在此，我们探索了Ca-EDTA与氨曲南或头孢他啶-阿维巴坦联合使用，并针对多种CPKp临床分离株进行研究。本研究的协同测试表明，新型氨曲南-Ca-EDTA或头孢他啶-阿维巴坦-Ca-EDTA联合用药在消除浮游菌和成熟生物膜以及根除CPKp感染方面具有显著效果。两种联合用药在降低内部器官中的细菌载量以及保护受试小鼠免于死亡方面均显示出显著的治疗效果。总之，这是首次证明新型氨曲南-Ca-EDTA或头孢他啶-阿维巴坦-Ca-EDTA联合用药在成功根除产碳青霉烯酶的浮游菌和生物膜感染方面具有良好疗效和安全性的研究。
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