Monitoring of Infection and Drug Resistance in 17 Pediatric Intensive Care Units in China from 2016 to 2022.

OBJECTIVE

To investigate the characteristics and drug resistance patterns of Klebsiella pneumoniae () infection in pediatric intensive care unit (PICU).

METHODS

strains from 17 domestic PICUs were analyzed for overall condition and drug resistance using WHO-NET software.

RESULTS

From 2016 to 2022, there was a linear increase in the detection rate of (P<0.05), with a total of 2591 (9.7%) strains detected. The primary sites of detection were the respiratory tract (71.1%), blood (8.6%), and urinary tract (7.1%). 's resistance to penicillin drugs exceeded 90%, and are over 50% to cephalosporins. Resistance to cefoperazone-sulbactam decreased from 51.7% to 25.7%, and ranged from 9.1% to 20.8% for ceftolozane-tazobactam. Carbapenem-resistant strains constituted 32.3%. Resistance to imipenem and meropenem have decreased to 33.8% and 40.2%, while increased to 35.2% for ertapenem. Levofloxacin and amikacin resistance rates have decreased to 25.7% and 9.1%, but remain high at 63.8% for moxifloxacin and 44.6% for ciprofloxacin. demonstrated the lowest resistance rates to polymyxin B (0.9%), tigecycline (2.2%), and polymyxin E (3.1%). No strain of was resistant to both polymyxin B and meropenem. However, some strains showed co-resistance to meropenem with other antibiotics, including tigecycline (2%), imipenem (16%), amikacin (27%), colistin (37%), and levofloxacin (41%).

CONCLUSION

The rates of isolation and drug resistance of in PICU have significantly increased over 7 years. Careful antibiotic use, infection control strategies, and appropriate antibiotic combinations are crucial in addressing this problem.