Muñoz Lezcano Sergio, Armengol de la Hoz Miguel Ángel, Corbi Alberto, López Fernando, García Miguel Sánchez, Reiz Antonio Nuñez, González Tomás Fariña, Zlatkov Viktor Yordanov
PhD Student of the Program in Computer Science, Universidad Internacional de La Rioja (UNIR), Avenida de La Paz, 137, 26006 Logroño, La Rioja, Spain.
Big Data Department, PMC-FPS, Consejería de Salud y Consumo, Junta de Andalucía, Spain.
Med Intensiva (Engl Ed). 2024 Jan;48(1):3-13. doi: 10.1016/j.medine.2023.07.009. Epub 2023 Jul 25.
To determine if potential predictors for invasive mechanical ventilation (IMV) are also determinants for mortality in COVID-19-associated acute respiratory distress syndrome (C-ARDS).
Single center highly detailed longitudinal observational study.
Tertiary hospital ICU: two first COVID-19 pandemic waves, Madrid, Spain.
280 patients with C-ARDS, not requiring IMV on admission.
None.
Target: endotracheal intubation and IMV, mortality.
demographics, hourly evolution of oxygenation, clinical data, and laboratory results.
The time between symptom onset and ICU admission, the APACHE II score, the ROX index, and procalcitonin levels in blood were potential predictors related to both IMV and mortality. The ROX index was the most significant predictor associated with IMV, while APACHE II, LDH, and DaysSympICU were the most with mortality.
According to the results of the analysis, there are significant predictors linked with IMV and mortality in C-ARDS patients, including the time between symptom onset and ICU admission, the severity of the COVID-19 waves, and several clinical and laboratory measures. These findings may help clinicians to better identify patients at risk for IMV and mortality and improve their management.
确定有创机械通气（IMV）的潜在预测因素是否也是新型冠状病毒肺炎相关急性呼吸窘迫综合征（C-ARDS）患者死亡的决定因素。
单中心高度详细的纵向观察性研究。
三级医院重症监护病房：西班牙马德里，新型冠状病毒肺炎疫情的前两波。
280例C-ARDS患者，入院时不需要IMV。
无。
目标：气管插管和IMV、死亡率。
人口统计学、氧合的每小时变化、临床数据和实验室检查结果。
症状出现至入住重症监护病房的时间、急性生理与慢性健康状况评分系统II（APACHE II）评分、ROX指数和血液中的降钙素原水平是与IMV和死亡率相关的潜在预测因素。ROX指数是与IMV相关的最显著预测因素，而APACHE II、乳酸脱氢酶（LDH）和症状出现至入住重症监护病房的天数是与死亡率相关的最显著因素。
根据分析结果，C-ARDS患者中存在与IMV和死亡率相关的显著预测因素，包括症状出现至入住重症监护病房的时间、新型冠状病毒肺炎疫情的严重程度以及多项临床和实验室指标。这些发现可能有助于临床医生更好地识别有IMV和死亡风险的患者，并改善对他们的管理。
