Department of Sport, Exercise and Health, Division Sport and Exercise Medicine, Section Rehabilitative and Regenerative Sport Medicine, University of Basel, Grosse Allee 6, CH-4052 Basel, Switzerland.
Department of Sport, Exercise and Health, Division Sport and Exercise Medicine, Section Rehabilitative and Regenerative Sport Medicine, University of Basel, Grosse Allee 6, CH-4052 Basel, Switzerland.
Nutr Metab Cardiovasc Dis. 2023 Oct;33(10):1907-1913. doi: 10.1016/j.numecd.2023.05.029. Epub 2023 Jun 5.
Heart failure is considered as a systemic disease as beside the heart, skeletal muscle is affected.
In this retrospective case-control study 64 men and 15 women with heart failure as well as an individually pairwise matched sample by sex, age and body mass index of healthy individuals from the COmPLETE cohort study performed an exhaustive cardiopulmonary exercise test, strength tests and anthropometric measurements. V̇Opeak was 28.6% lower in male and 24.6% lower in female patients with heart failure as compared to healthy controls. Strength parameters are significantly higher for counter movement jump in male subjects. In females, significant differences were detected for mid-thigh pull in healthy versus patients with heart failure. Skeletal muscle mass of patients was in male as well as female 3.7% lower than in controls. Furthermore, the function of skeletal muscle seems impaired as the ability to accelerate is significantly lower in affected male with a heart pathology.
It seems that severe affections (approx. 25 to 30%) on cardiocirculatory level are associated with moderate to low affections on functional and structural capacity on skeletal muscle level. Further, as in the male cohort with a heart pathology acceleration meaning 'fast' contracting is impaired, it is suggested, that the central limitations respectively the low perfusion of skeletal muscle over years yield to adaptions on muscle cell level ingoing with a decreased ability of fast contracting. It is therefore suggested, that the central circulatory limitations in patients with heart failure, respectively the low perfusion of skeletal muscle over years, promote maladaptation's in the periphery.
心力衰竭被认为是一种全身性疾病，除了心脏，骨骼肌也会受到影响。
在这项回顾性病例对照研究中，我们招募了 64 名男性和 15 名女性心力衰竭患者，以及来自 COmPLETE 队列研究的健康个体，通过性别、年龄和体重指数进行个体配对，所有参与者都进行了全面的心肺运动试验、力量测试和人体测量学测量。与健康对照组相比，男性心力衰竭患者的 V̇Opeak 降低了 28.6%，女性心力衰竭患者的 V̇Opeak 降低了 24.6%。男性受试者的反向跳跃测试的力量参数明显更高。在女性中，健康对照组与心力衰竭患者组在大腿中段拉力测试中存在显著差异。与对照组相比，心力衰竭患者的骨骼肌质量在男性和女性中分别低 3.7%。此外，由于患有心脏疾病的男性的加速能力显著降低，骨骼肌的功能似乎受损，这表明心血管功能的严重损伤（约 25%至 30%）与骨骼肌功能和结构能力的中度至轻度损伤有关。此外，由于患有心脏疾病的男性的加速度（即快速收缩）受损，因此有人认为，多年来骨骼肌的中央限制或低灌注导致了肌肉细胞水平的适应，随之而来的是快速收缩能力的下降。因此，建议心力衰竭患者的中央循环限制，或骨骼肌多年的低灌注，会促进外周的适应性不良。
