Weigel Lucia, Wehr Sophia, Galderisi Silvana, Mucci Armida, Davis John, Giordano Giulia Maria, Leucht Stefan
Department of Psychiatry and Psychotherapy, School Of Medicine, Technical University of Munich, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675, Munich, Germany.
Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Largo Madonna delle Grazie 1, 80138, Naples, Italy.
Schizophrenia (Heidelb). 2023 Jul 27;9(1):45. doi: 10.1038/s41537-023-00380-x.
Negative symptoms of schizophrenia are linked with poor functioning and quality of life. Therefore, appropriate measurement tools to assess negative symptoms are needed. The NIMH-MATRICS Consensus defined five domains for negative symptoms, which The Brief Negative Symptom Scale (BNSS) covers.
We used the COSMIN guidelines for systematic reviews to evaluate the quality of psychometric data of the BNSS scale as a Clinician-Rated Outcome Measure (ClinROM).
The search strategy resulted in the inclusion of 17 articles. When using the risk of bias checklist, there was a generally good quality in reporting of structural validity and hypothesis testing. Internal consistency, reliability and cross-cultural validity were of poorer quality. ClinROM development and content validity showed inadequate results. According to the updated criteria of good measurement properties, structural validity, internal consistency and interrater reliability showed good results, while hypothesis testing showed poorer results. Cross-cultural validity and test-retest reliability were indeterminate. The updated GRADE approach resulted in a moderate grade.
We can potentially recommend the use of the BNSS as a concise tool to rate negative symptoms. Due to weaknesses in certain domains further validations are warranted.
精神分裂症的阴性症状与功能不良和生活质量相关。因此,需要合适的测量工具来评估阴性症状。美国国立精神卫生研究所(NIMH)-精神分裂症治疗与干预评价临床试验标准(MATRICS)共识确定了阴性症状的五个领域,简明阴性症状量表(BNSS)涵盖了这些领域。
我们使用COSMIN系统评价指南来评估作为临床医生评定结局指标(ClinROM)的BNSS量表心理测量数据的质量。
检索策略纳入了17篇文章。使用偏倚风险清单时,结构效度和假设检验的报告质量总体良好。内部一致性、信度和跨文化效度质量较差。ClinROM的开发和内容效度结果不充分。根据良好测量特性的更新标准,结构效度、内部一致性和评分者间信度显示出良好结果,而假设检验结果较差。跨文化效度和重测信度不确定。更新后的GRADE方法得出中等等级。
我们可能推荐使用BNSS作为评定阴性症状的简明工具。由于某些领域存在不足,需要进一步验证。