Shipton E A, Hugo J M, Müller F O
S Afr Med J. 1986 Sep 13;70(6):325-8.
Epidural fentanyl (Sublimaze; Janssen) in the management of postoperative pain, with particular attention to efficacy and safety, was investigated. A treatment group (group 1) of 31 patients and a control group (group 2) of 30 patients were used. Group 1 received epidural fentanyl 100 micrograms postoperatively, while in the control group pain was treated with intramuscular pethidine 1.5 mg/kg 4-6-hourly as required during the 11 hours in the recovery room. Epidural fentanyl started working within 20 minutes and provided excellent analgesia for 8 hours or more postoperatively, comparable to repeated doses of intramuscular pethidine. Of the patients in group 1 13% experienced tolerable pruritus and the incidence of nausea and vomiting was small relative to that recorded in group 2.
研究了硬膜外注射芬太尼（苏芬太尼；杨森公司生产）用于术后疼痛管理，尤其关注其有效性和安全性。使用了一个由31名患者组成的治疗组（第1组）和一个由30名患者组成的对照组（第2组）。第1组患者术后接受100微克硬膜外芬太尼，而在对照组中，在恢复室的11小时内，根据需要每4 - 6小时肌肉注射1.5毫克/千克哌替啶来治疗疼痛。硬膜外芬太尼在20分钟内开始起效，术后提供了8小时或更长时间的良好镇痛效果，与重复肌肉注射哌替啶相当。第1组中有13%的患者出现了可耐受的瘙痒，且恶心和呕吐的发生率相对于第2组记录的发生率较低。
