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使用双层微网支架的颈动脉支架置入术

Carotid Artery Stenting Using a Double-layer Micromesh Stent.

作者信息

Yamada Kiyofumi, Yoshimura Shinichi, Yoshida Kazumichi, Uchida Kazutaka, Shirakawa Manabu, Kawasaki Masanori, Miura Masatomo, Ishii Akira, Kataoka Hiroharu, Miyamoto Susumu

机构信息

Department of Neurosurgery, Kyoto University, Kyoto, Kyoto, Japan.

Department of Neurosurgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

出版信息

J Neuroendovasc Ther. 2020;14(10):407-412. doi: 10.5797/jnet.ra.2020-0066. Epub 2020 Jul 21.

Abstract

Carotid artery stenting (CAS) has recently emerged as a potential alternative to carotid endarterectomy (CEA) in Japan. However, one of its disadvantages is the higher incidence of ischemic complications than CEA, such as distal embolism during or after the procedure. Plaque protrusion (PP) through the stent strut after deployment of the stent has been suggested as one of the major causes of distal embolism, especially in patients with unstable plaques. The need for increased plaque coverage to reduce the risk of PP through the stent struts has led to the development of a double-layer micromesh stent (micromesh stent) system. This stent system has already been used clinically in European countries with good short- to medium-term follow-up results. Also clinical trials evaluating micromesh stents have been completed in Japan. Hence, usefulness of the micromesh stent for CAS is expected. According to the results of several clinical studies, CAS with the double-layer micromesh stent has the potential to minimize distal embolism during or after the procedure even in patients with unstable plaques. However, it may not be suitable for emergency CAS at this point. Also, since results of only short- to medium-term follow-up have been reported, longer-term follow-up will be required in the near future.

摘要

最近在日本,颈动脉支架置入术(CAS)已成为颈动脉内膜切除术(CEA)的一种潜在替代方法。然而,其缺点之一是缺血性并发症的发生率高于CEA,例如在手术期间或术后发生远端栓塞。支架置入后斑块通过支架小梁突出(PP)被认为是远端栓塞的主要原因之一,尤其是在不稳定斑块患者中。为降低斑块通过支架小梁突出的风险而增加斑块覆盖率的需求促使了双层微孔支架(微孔支架)系统的研发。该支架系统已在欧洲国家临床应用,短期至中期随访结果良好。日本也已完成评估微孔支架的临床试验。因此,预期微孔支架对CAS有用。根据多项临床研究结果,即使对于不稳定斑块患者,使用双层微孔支架的CAS也有可能在手术期间或术后将远端栓塞降至最低。然而,目前它可能不适用于急诊CAS。此外,由于仅报道了短期至中期随访结果,在不久的将来还需要进行长期随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2807/10370536/1639b224f1b9/jnet-14-407-g001.jpg

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