Wakabayashi Y, Sakamoto H, Mishina T, Marumo F
Tohoku J Exp Med. 1986 Jun;149(2):145-50. doi: 10.1620/tjem.149.145.
The electrolyte and acid base composition of steady state chronic renal failure patients were studied. A particular comparison was made between the group of hyperchloremic and normochloremic patients, matched for sex, age, serum creatinine concentration and the etiology of the disease. Hyperchloremia was constantly seen in any stage of the disease in hyperchloremic patients, and they were found to be more acidemic, with lower anion gap, than normochloremic patients. A greater degree of tubular dysfunction than glomerular dysfunction was considered as the cause of acidosis and hyperchloremia in any stage of the disease. Hyperchloremia could be an indication to initiate alkali therapy to protect against further loss of bone mineral and the progression of the disease itself.
对慢性肾衰竭稳态患者的电解质和酸碱组成进行了研究。对高氯血症患者和正常氯血症患者进行了特别比较，两组在性别、年龄、血清肌酐浓度和疾病病因方面相匹配。高氯血症患者在疾病的任何阶段均持续出现高氯血症，并且发现他们比正常氯血症患者的酸中毒程度更高，阴离子间隙更低。在疾病的任何阶段，肾小管功能障碍程度大于肾小球功能障碍被认为是酸中毒和高氯血症的原因。高氯血症可能是开始碱治疗以防止骨矿物质进一步流失和疾病本身进展的一个指征。
