Widmer B, Gerhardt R E, Harrington J T, Cohen J J
Arch Intern Med. 1979 Oct;139(10):1099-102.
Data from 41 ambulatory patients with graded degrees of uncomplicated, chronic renal failure were used to define the quantitative relationship between serum acid-base and electrolyte composition and the serum creatinine level. Even in patients with only moderate renal insufficiency, serum total carbon dioxide (tCO2) content was reduced significantly. This early fall in tCO2 was offset by an increase in serum chloride (Cl-), serum undetermined anton concentration (A-) remaining normal. In patients with more severe degrees of renal insufficiency, further decrements in tCO2 occurred that were proportional to the increment in serum creatinine. These latter decrements in tCO2 were associated with equivalent increments in A-, serum Cl- remaining unchanged at the elevated level observed during moderate renal insufficiency. Confidence limits of 95% for tCO2 and A- were calculated from the data.
来自41例非复杂性慢性肾功能衰竭分级患者的数据被用于确定血清酸碱和电解质组成与血清肌酐水平之间的定量关系。即使在仅有中度肾功能不全的患者中，血清总二氧化碳（tCO2）含量也显著降低。tCO2的这种早期下降被血清氯（Cl-）的增加所抵消，血清未测定阴离子浓度（A-）保持正常。在肾功能不全程度更严重的患者中，tCO2进一步下降，且与血清肌酐的增加成比例。tCO2的这些后期下降与A-的等量增加相关，血清Cl-在中度肾功能不全期间观察到的升高水平保持不变。根据这些数据计算了tCO2和A-的95%置信限。
