Yamauchi H, Takahashi K, Yamamura Y
Toxicology. 1986 Sep;40(3):237-46. doi: 10.1016/0300-483x(86)90056-9.
This study deals with the metabolism of gallium arsenide (GaAs). GaAs was shown to be soluble in various media. Since this compound could dissolve in aqueous solvents, in vivo dissolution was investigated. Hamsters were used to study the dissolution and subsequent pharmacokinetics of any liberated arsenic species. The fecal and urinary excretion data following oral and intraperitoneal administration showed that GaAs, when administered orally, is mostly excreted in the feces but poorly in the urine, and that the compound, when administered intraperitoneally, is poorly excreted in both the feces and urine. Analysis of tissues for arsenic levels yielded concentrations in the ppb range, which further verified this fact. Most interesting was the fact that dimethylarsinic acid (DMAA) and methylarsonic acid (MAA) along with inorganic arsenic were found in the urine and tissues. GaAs was shown to dissolve in vivo and the released arsenic species were metabolized as other inorganic arsenics were found in the urine and tissues. GaAs was shown to dissolve in vivo and the released arsenic species were metabolized as other inorganic arsenic containing compounds. The low solubility and poor oral absorption may make this compound less toxic than other inorganic arsenic compounds.
本研究涉及砷化镓（GaAs）的代谢。研究表明GaAs可溶于多种介质。由于该化合物可溶于水性溶剂，因此对其体内溶解情况进行了研究。使用仓鼠来研究任何释放出的砷物种的溶解及后续药代动力学。口服和腹腔注射给药后的粪便和尿液排泄数据表明，口服GaAs时，大部分经粪便排泄，经尿液排泄较少；而腹腔注射该化合物时，经粪便和尿液排泄均较少。对组织中砷含量的分析得出的浓度在十亿分比范围内，这进一步证实了这一事实。最有意思的是，在尿液和组织中发现了二甲基胂酸（DMAA）、甲基胂酸（MAA）以及无机砷。研究表明GaAs在体内会溶解，释放出的砷物种会像尿液和组织中发现的其他无机砷一样发生代谢。研究表明GaAs在体内会溶解，释放出的砷物种会像其他含无机砷的化合物一样发生代谢。其低溶解度和较差的口服吸收性可能使该化合物的毒性低于其他无机砷化合物。
