Yamauchi H, Yamamura Y
Toxicol Appl Pharmacol. 1984 Jun 15;74(1):134-40. doi: 10.1016/0041-008x(84)90279-5.
We administered a single po dose of dimethylarsinic acid ( DMAA ) to hamsters by stomach tube and determined the in vivo accumulation of the arsenic and its excretion in the urine and feces. It was shown that a part of the DMAA was further methylated to a trimethylarsenic compound (TMA). During the 24 hr following the administration of DMAA , a total of 80% was excreted in the urine and feces: 45% in the urine (made up of 67.9% DMAA and 32.0% TMA), and 34.7% in the feces (almost completely made up of DMAA but no TMA). The findings show that DMAA and the TMA are rapidly excreted and do not accumulate in the body.
我们通过胃管给仓鼠单次口服二甲基胂酸（DMAA），并测定了砷在体内的蓄积情况及其在尿液和粪便中的排泄情况。结果表明，一部分DMAA进一步甲基化形成三甲基砷化合物（TMA）。在给予DMAA后的24小时内，总共80%通过尿液和粪便排出：45%通过尿液排出（由67.9%的DMAA和32.0%的TMA组成），34.7%通过粪便排出（几乎完全由DMAA组成，不含TMA）。研究结果表明，DMAA和TMA排泄迅速，不会在体内蓄积。
