Jorgensen S E, Mulcahy P F, Louis C F
Toxicon. 1986;24(6):559-66. doi: 10.1016/0041-0101(86)90176-5.
The extracellular hemolysin produced by porcine strains of E. coli effects a marked increase in the calcium permeability of erythrocyte membranes. This hemolysin promotes both calcium efflux from either calcium-loaded erythrocytes or erythrocyte ghosts and calcium accumulation during the pre-lytic period. Erythrocyte membrane calcium permeability was determined using either the radioisotope 45Ca or a calcium electrode. When similar concentrations of erythrocytes (35% packed cell volume) were treated with increasing amounts of hemolysin there was an increase in both the rate and the extent of calcium accumulation by the erythrocytes. These increases were due to increased numbers of erythrocytes becoming permeable to calcium as hemolysin concentrations increased, rather than increasing amounts of calcium being accumulated by individual erythrocytes. Hemolysins produced by porcine strains of E. coli from five geographical areas all increased calcium permeability of erythrocyte membranes.
猪源大肠杆菌菌株产生的细胞外溶血素可使红细胞膜的钙通透性显著增加。这种溶血素既能促进钙从钙负载的红细胞或红细胞血影中流出，又能促进溶血前期钙的积累。使用放射性同位素45Ca或钙电极测定红细胞膜的钙通透性。当用越来越多的溶血素处理相似浓度的红细胞（35%的红细胞压积）时，红细胞钙积累的速率和程度均增加。这些增加是由于随着溶血素浓度的增加，越来越多的红细胞对钙变得通透，而不是单个红细胞积累的钙量增加。来自五个地理区域的猪源大肠杆菌菌株产生的溶血素均增加了红细胞膜的钙通透性。
