One-pot multicomponent synthesis of novel pyridine derivatives for antidiabetic and antiproliferative activities.

Due to the close relationship of diabetes with hypertension reported in various research, a set of pyridine derivatives with US FDA-approved drug cores were designed and integrated by artificial intelligence. Novel pyridines were designed and synthesized. Compounds - were evaluated for their structure and were screened for their antidiabetic (α-amylase) activity and anticancer (HepG2) activity by methyl thiazolyl tetrazolium assay. Comparative 3D quantitative structure-activity relationship analysis and pharmacophore generation were carried out. The study revealed and as good alternatives to acarbose as antidiabetic agents, and as a more viable, better alternative to doxorubicin in the methyl thiazolyl tetrazolium assay. This combination of studies identifies new and more active analogs of existing FDA-approved drugs for the treatment of diabetes.