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破解密码：氨基吡啶的临床与分子影响；综述（2019 - 2024年）

Cracking the code: the clinical and molecular impact of aminopyridines; a review (2019-2024).

作者信息

Khalid Tahira, Malik Ayesha, Rasool Nasir, Kanwal Aqsa, Nawaz Hamna, Almas Iffat

机构信息

Department of Chemistry, Government College University Faisalabad Faisalabad 38000 Pakistan

出版信息

RSC Adv. 2025 Jan 8;15(1):688-711. doi: 10.1039/d4ra07438f. eCollection 2025 Jan 2.

DOI:10.1039/d4ra07438f
PMID:39781020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11708541/
Abstract

Aminopyridines belong to a class of compounds that are monoamino and diamino derivatives of pyridine. They work primarily by blocking voltage-gated potassium channels in a dose-dependent manner. Essential heterocycles used extensively in synthetic, natural products, and medicinal chemistry are aminopyridine and its derivatives. A vast array of biological and pharmacological effects can result from the interaction of aminopyridine rings with different enzymes and receptors, due to their unique structural properties. Aminopyridine research is continually growing, and there are now greater expectations for how it may aid in the treatment of numerous disorders. This review article will serve as an innovative platform for researchers investigating aminopyridine compounds, intending thoroughly to examine both traditional and novel synthesis strategies in addition to investigating the various biological characteristics displayed by these adaptable heterocycles. We attempt to provide valuable insights that will contribute to further progress in the synthesis and utilization of aminopyridines in various fields.

摘要

氨基吡啶属于吡啶的单氨基和二氨基衍生物类化合物。它们主要通过剂量依赖性方式阻断电压门控钾通道发挥作用。氨基吡啶及其衍生物是在合成、天然产物和药物化学中广泛使用的重要杂环。由于其独特的结构特性，氨基吡啶环与不同酶和受体的相互作用可产生大量生物学和药理学效应。氨基吡啶的研究不断发展，目前人们对其在治疗多种疾病方面的帮助寄予了更高期望。这篇综述文章将为研究氨基吡啶化合物的研究人员提供一个创新平台，旨在除了研究这些适应性强的杂环所展现的各种生物学特性外，还将全面审视传统和新型合成策略。我们试图提供有价值的见解，这将有助于氨基吡啶在各个领域的合成和利用取得进一步进展。

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Cancer Rep (Hoboken). 2024 Dec;7(12):e70072. doi: 10.1002/cnr2.70072.
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LINC-PINT plays an anti-tumor role in nasopharyngeal carcinoma by binding to XRCC6 and affecting its function.LINC-PINT 通过与 XRCC6 结合并影响其功能在鼻咽癌中发挥抑癌作用。
Pathol Res Pract. 2024 Aug;260:155460. doi: 10.1016/j.prp.2024.155460. Epub 2024 Jul 18.
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Molecular modeling of novel 2-aminopyridine derivatives as potential JAK2 inhibitors: a rational strategy for promising anticancer agents.
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J Biomol Struct Dyn. 2024 Mar 6:1-16. doi: 10.1080/07391102.2024.2324345.
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A novel bi-functional cold-adaptive chitinase from Chitinilyticum aquatile CSC-1 for efficient synthesis of N-acetyl-D-glucosaminidase.一种新型的冷适应双功能甲壳素酶，来自水生甲壳质分解菌 CSC-1，可有效合成 N-乙酰-D-氨基葡萄糖苷酶。
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