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[已撤回] 长期酒精暴露会通过PI3K/Akt/IKK加重炎症并引发胰腺腺泡-导管化生。

[Retracted] Chronic alcohol exposure exacerbates inflammation and triggers pancreatic acinar‑to‑ductal metaplasia through PI3K/Akt/IKK.

作者信息

Huang Xin, Li Xuqi, Ma Qingyong, Xu Qinhong, Duan Wanxing, Lei Jianjun, Zhang Lun, Wu Zheng

机构信息

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China.

Department of General Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China.

出版信息

Int J Mol Med. 2023 Sep;52(3). doi: 10.3892/ijmm.2023.5285. Epub 2023 Jul 28.

Abstract

Following the publication of the above article, a concerned reader drew to the Editor's attention that there were a number of apparent anomalies associated with the western blots featured in Figs. 1C and E, 3A, C and E, 4A, C and E, 5B, 8A and C; moreover, the images shown for the immunohistochemical experiments in Fig. 8E contained groupings of cells that were markedly similar in appearance, comparing across the eight separate figure parts. After having conducted an internal investigation of the data in this paper, the Editor of has judged that the potentially anomalous presentation of the western blotting data and the strikingly similar groupings of cells in Fig. 8E were too extensive that these features could have been attributed to pure coincidence. Therefore, the Editor has decided that this article should be retracted from the publication on the grounds of an overall lack of confidence in the data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor sincerely apologizes to the readership for any incovenience caused, and we thank the reader for bringing this matter to our attention. [International Journal of Molecular Medicine 35: 653‑663, 2015; DOI: 10.3892/ijmm.2014.2055].

摘要

上述文章发表后,一位关注此事的读者提请编辑注意,图1C和E、3A、C和E、4A、C和E、5B、8A和C中的蛋白质免疫印迹存在一些明显异常;此外,图8E中免疫组织化学实验所示的图像包含外观明显相似的细胞群,这些细胞群分布在八个不同的图部分中。在对本文数据进行内部调查后,《国际分子医学杂志》的编辑判定,蛋白质免疫印迹数据的潜在异常呈现以及图8E中细胞群惊人的相似性太过广泛,不可能是纯粹的巧合。因此,编辑决定基于对数据整体缺乏信心,从出版物中撤回本文。已要求作者对这些问题作出解释,但编辑部未收到答复。编辑就由此造成的不便向读者致以诚挚歉意,同时感谢读者提醒我们关注此事。[《国际分子医学杂志》35: 653 - 663, 2015; DOI: 10.3892/ijmm.2014.2055]

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