Lee H S, Yeoh T S, Lee A S, Ho N K, Ti T Y
Ther Drug Monit. 1986;8(3):377-9. doi: 10.1097/00007691-198609000-00026.
The Amerlex digoxin radioimmunoassay was modified to reduce the running cost by five times. The modified method compared well with the original method (y = 1.0138x + 0.00916, r = 0.9936). Using the modified method, the performance with the American Association for Clinical Chemistry quality control program was consistently satisfactory for 1 year. When normal cord and neonatal sera were tested with the modified method, 41% of the 22 samples of cord serum and 68% of the 19 samples of neonatal serum produced digoxin levels less than or equal to 0.05 ng/ml. The highest digoxin level produced by cord and neonatal sera was 0.3 ng/ml.
对Amerlex地高辛放射免疫分析法进行了改进，以使运行成本降低五倍。改进后的方法与原方法相比效果良好（y = 1.0138x + 0.00916，r = 0.9936）。使用改进后的方法，在1年时间里，美国临床化学协会质量控制项目的性能一直令人满意。当用改进后的方法检测正常脐带血和新生儿血清时，22份脐带血样本中有41%以及19份新生儿血清样本中有68%的地高辛水平小于或等于0.05 ng/ml。脐带血和新生儿血清产生的最高地高辛水平为0.3 ng/ml。
