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基于丝网印刷的纺织品电化学生物传感器,用于无创监测汗液中的葡萄糖。

Screen-Printed Textile-Based Electrochemical Biosensor for Noninvasive Monitoring of Glucose in Sweat.

机构信息

Flexible Electronics and Energy Lab (FEEL), Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA.

出版信息

Biosensors (Basel). 2023 Jun 27;13(7):684. doi: 10.3390/bios13070684.

Abstract

Wearable sweat biosensors for noninvasive monitoring of health parameters have attracted significant attention. Having these biosensors embedded in textile substrates can provide a convenient experience due to their soft and flexible nature that conforms to the skin, creating good contact for long-term use. These biosensors can be easily integrated with everyday clothing by using textile fabrication processes to enhance affordable and scalable manufacturing. Herein, a flexible electrochemical glucose sensor that can be screen-printed onto a textile substrate has been demonstrated. The screen-printed textile-based glucose biosensor achieved a linear response in the range of 20-1000 µM of glucose concentration and high sensitivity (18.41 µA mM cm, R = 0.996). In addition, the biosensors show high selectivity toward glucose among other interfering analytes and excellent stability over 30 days of storage. The developed textile-based biosensor can serve as a platform for monitoring bio analytes in sweat, and it is expected to impact the next generation of wearable devices.

摘要

可穿戴汗液生物传感器可实现对健康参数的非侵入式监测,因此受到了广泛关注。将这些生物传感器嵌入纺织基底中,由于其柔软灵活的特性与皮肤贴合,可提供更为便捷的使用体验,有助于实现长期使用。通过采用纺织制造工艺,这些生物传感器可以很容易地与日常衣物集成,从而实现更具成本效益和规模化的制造。本文展示了一种可通过丝网印刷技术印在纺织基底上的柔性电化学葡萄糖传感器。所制备的基于丝网印刷的纺织葡萄糖生物传感器在 20-1000µM 的葡萄糖浓度范围内呈现出线性响应和高灵敏度(18.41µA mM cm,R = 0.996)。此外,该生物传感器对葡萄糖以外的其他干扰分析物具有较高的选择性,在 30 天的储存过程中表现出良好的稳定性。所开发的基于纺织的生物传感器可作为监测汗液中生物分析物的平台,有望推动下一代可穿戴设备的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f28/10377550/c8e2156161fe/biosensors-13-00684-g001.jpg

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