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用于自泵送汗液采样与分析的集成智能双面纺织带

Integrated Smart Janus Textile Bands for Self-Pumping Sweat Sampling and Analysis.

作者信息

He Xuecheng, Yang Shijie, Pei Quanbing, Song Yongchao, Liu Conghui, Xu Tailin, Zhang Xueji

机构信息

Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, 30 Xueyuan Road, Beijing 100083, P. R. China.

Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), School of Biomedical Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.

出版信息

ACS Sens. 2020 Jun 26;5(6):1548-1554. doi: 10.1021/acssensors.0c00563. Epub 2020 Jun 4.

Abstract

Wearable sweat sensors have spearheaded the thrust toward personalized health monitoring with continuous, real-time, and molecular-level insight in a noninvasive manner. However, effective sweat sampling still remains a huge challenge. Here, we introduce an intelligent Janus textile band that bridges the gap between self-pumping sweat collection, comfortable epidemic microclimate, and sensitive electrochemical biosensing via an integrated wearable platform. The dominant sweat sampling configuration is a textile with Janus wettability, which is fabricated by electrospinning a hydrophobic polyurethane (PU) nanofiber array onto superhydrophilic gauze. Based on a contact-pumping model, the Janus textile can unidirectionally and thoroughly transport sweat from skin (hydrophobic side) to embedded electrode surface (hydrophilic side) with epidemic comfort. On-body experimentation reveals that the sensitive detection of multiple biomarkers including glucose, lactate, K, and Na is achieved in the pumped sweat. Such smart Janus textile bands can effectively drain epidermal sweat to targeted assay sites via interface modifications, representing a reinforced and controlled biofluids analysis pathway with physiological comfort.

摘要

可穿戴汗液传感器率先推动了以无创方式进行连续、实时和分子水平洞察的个性化健康监测。然而,有效的汗液采样仍然是一个巨大的挑战。在此,我们介绍一种智能Janus纺织带,它通过一个集成的可穿戴平台弥合了自抽汗收集、舒适的流行微气候和灵敏的电化学生物传感之间的差距。主要的汗液采样结构是具有Janus润湿性的纺织品,它是通过将疏水性聚氨酯(PU)纳米纤维阵列电纺到超亲水性纱布上制成的。基于接触泵送模型,Janus纺织品能够在保证流行舒适度的情况下,将汗液从皮肤(疏水侧)单向且彻底地输送到嵌入式电极表面(亲水侧)。人体实验表明,在泵送的汗液中能够实现对包括葡萄糖、乳酸、钾和钠在内的多种生物标志物的灵敏检测。这种智能Janus纺织带可以通过界面修饰有效地将表皮汗液引流到目标检测部位,代表了一种具有生理舒适度的强化且可控的生物流体分析途径。

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