Kharkova Anna S, Kuznetsova Lubov S, Ivanova Kristina D, Gertsen Maria M, Arlyapov Vyacheslav A
Research Center "BioChemTech", Tula State University, Tula, Russia.
Laboratory of Soil Chemistry and Ecology, Faculty of Natural Sciences, Tula State Lev Tolstoy Pedagogical University, Tula, Russia.
Curr Top Med Chem. 2025;25(7):741-760. doi: 10.2174/0115680266323004241015122441.
Amperometric biosensors have emerged as a cutting-edge technology in clinical diagnostics, thanks to their high level of sensitivity, rapid analytical results, compact size, and ability to monitor health parameters non-invasively and continuously using flexible and wearable sensors. This review explores the latest developments in the field of amperometric biosensing for medical applications. It discusses the materials used to construct these sensors and pays particular attention to biosensors designed to measure glucose, lactate, cholesterol, urea, and uric acid levels. The review also addresses the technological limitations and drawbacks of these devices. Furthermore, it presents the current status and identifies future trends in the development of flexible, wearable biosensors capable of providing continuous monitoring of a patient's health status.
由于具有高灵敏度、快速分析结果、紧凑尺寸以及能够使用灵活的可穿戴传感器进行无创和连续健康参数监测的能力,电流型生物传感器已成为临床诊断中的一项前沿技术。本综述探讨了用于医学应用的电流型生物传感领域的最新进展。它讨论了用于构建这些传感器的材料,并特别关注设计用于测量葡萄糖、乳酸、胆固醇、尿素和尿酸水平的生物传感器。该综述还讨论了这些设备的技术局限性和缺点。此外,它介绍了能够持续监测患者健康状况的柔性可穿戴生物传感器的发展现状并确定了未来趋势。