Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Laboratory of Bio-Physio Sensors and Nanobioengineering, School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi 221005, India.
Biosensors (Basel). 2023 Jul 17;13(7):740. doi: 10.3390/bios13070740.
A monolayer of boron known as borophene has emerged as a novel and fascinating two-dimensional (2D) material with exceptional features, such as anisotropic metallic behavior and supple mechanical and optical capabilities. The engineering of smart functionalized opto-electric 2D materials is essential to obtain biosensors or biodevices of desired performance. Borophene is one of the most emerging 2D materials, and owing to its excellent electroactive surface area, high electron transport, anisotropic behavior, controllable optical and electrochemical properties, ability to be deposited on thin films, and potential to create surface functionalities, it has recently become one of the sophisticated platforms. Despite the difficulty of production, borophene may be immobilized utilizing chemistries, be functionalized on a flexible substrate, and be controlled over electro-optical properties to create a highly sensitive biosensor system that could be used for point-of-care diagnostics. Its electrochemical properties can be tailored by using appropriate nanomaterials, redox mediators, conducting polymers, etc., which will be quite useful for the detection of biomolecules at even trace levels with a high sensitivity and less detection time. This will be quite helpful in developing biosensing devices with a very high sensitivity and with less response time. So, this review will be a crucial foundation as we have discussed the basic properties, synthesis, and potential applications of borophene in nanobiosensing, as well as therapeutic applications.
硼的单层，即硼烯，已成为一种新颖而引人注目的二维（2D）材料，具有各向异性金属行为以及柔韧的机械和光学性能等独特特征。设计智能功能化的光电 2D 材料对于获得具有理想性能的生物传感器或生物器件至关重要。硼烯是最具前景的 2D 材料之一，由于其出色的电活性表面积、高电子输运、各向异性行为、可控的光学和电化学性能、可在薄膜上沉积的能力以及创造表面功能的潜力，它最近成为了一种复杂的平台。尽管生产困难，但可以利用化学方法将硼烯固定化，在柔性基底上进行功能化，并控制其光电性能，从而创建高度灵敏的生物传感器系统，可用于即时诊断。通过使用适当的纳米材料、氧化还原介质、导电聚合物等，可调整其电化学性质，这对于以高灵敏度和更短的检测时间检测痕量生物分子非常有用。这将有助于开发具有非常高灵敏度和更短响应时间的生物传感设备。因此，本综述将是一个重要的基础，我们讨论了硼烯在纳米生物传感以及治疗应用中的基本性质、合成和潜在应用。
