Wang Qi, Qu Yanfei, Zhang Ziyi, Huang Hao, Xu Yufei, Shen Fengyun, Wang Lihua, Sun Lele
School of Life Sciences, Shanghai University, Shanghai 200444, China.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 201240, China.
Gels. 2022 Jun 24;8(7):400. doi: 10.3390/gels8070400.
Regulated drug delivery is an important direction in the field of medicine and healthcare research. In recent years, injectable hydrogels with good biocompatibility and biodegradability have attracted extensive attention due to their promising application in controlled drug release. Among them, DNA hydrogel has shown great potentials in local drug delivery and immunotherapy. DNA hydrogel is a three-dimensional network formed by cross-linking of hydrophilic DNA strands with extremely good biocompatibility. Benefiting from the special properties of DNA, including editable sequence and specificity of hybridization reactions, the mechanical properties and functions of DNA hydrogels can be precisely designed according to specific applications. In addition, other functional materials, including peptides, proteins and synthetic organic polymers can be easily integrated with DNA hydrogels, thereby enriching the functions of the hydrogels. In this review, we first summarize the types and synthesis methods of DNA hydrogels, and then review the recent research progress of injectable DNA hydrogels in local drug delivery, especially in immunotherapy. Finally, we discuss the challenges facing DNA hydrogels and future development directions.
调控药物递送是医学和医疗保健研究领域的一个重要方向。近年来，具有良好生物相容性和生物降解性的可注射水凝胶因其在药物控释方面的广阔应用前景而备受关注。其中，DNA水凝胶在局部药物递送和免疫治疗中显示出巨大潜力。DNA水凝胶是由具有极佳生物相容性的亲水性DNA链交联形成的三维网络。受益于DNA的特殊性质，包括可编辑序列和杂交反应的特异性，DNA水凝胶的机械性能和功能可以根据特定应用进行精确设计。此外，包括肽、蛋白质和合成有机聚合物在内的其他功能材料可以很容易地与DNA水凝胶整合，从而丰富水凝胶的功能。在这篇综述中，我们首先总结了DNA水凝胶的类型和合成方法，然后综述了可注射DNA水凝胶在局部药物递送，特别是免疫治疗方面的最新研究进展。最后，我们讨论了DNA水凝胶面临的挑战和未来的发展方向。
