di Cagno Alessandra, Fiorilli Giovanni, Buonsenso Andrea, Di Martino Giulia, Centorbi Marco, Angiolillo Antonella, Calcagno Giuseppe, Komici Klara, Di Costanzo Alfonso
Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.
Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.
J Cardiovasc Dev Dis. 2023 Jul 3;10(7):285. doi: 10.3390/jcdd10070285.
Although physical activity (PA) has been shown to enhance hypertension control, the impact of exercise on the potential decrease of the use of antihypertensive medications remains inadequately researched.
The aim was to assess the impact of a two-year PA on the medication requirements of individuals with hypertension.
A clinical trial was conducted, involving 130 participants with essential hypertension who took at least one antihypertensive medication. Participants were randomly assigned to either a control group (CG = 65) or an experimental group (EG = 65) that underwent a 24-month supervised PA program based on a combination of aerobic and resistance training. The antihypertensive drug load for each participant was determined by adding the ratios of the prescribed daily dose (PDD) to the defined daily dose (DDD) for all antihypertensive medications taken by the participants. The outcome measures were evaluated at 0, 6, 12, 18, and 24 months.
A total of 76 participants completed the 24-month assessment, and RM-ANOVA revealed a significantly lower antihypertensive drug load in the EG compared to the CG at 18 ( < 0.017) and 24 months ( < 0.003).
A long-term PA program can decrease the antihypertensive drug load in older adults with essential hypertension. The trend of improvement regarding the EG drug load intake and the trend of CG drug load increase, although not significant over time, results in a significant difference between the groups at 18 months and an even greater difference at 24 months. This trend certifies the protective value of PA against the aging process and its related health risk factors.
尽管体育活动（PA）已被证明可增强高血压控制，但运动对降压药物使用潜在减少的影响仍研究不足。
旨在评估为期两年的体育活动对高血压患者药物需求的影响。
进行了一项临床试验，纳入130名原发性高血压患者，他们至少服用一种降压药物。参与者被随机分为对照组（CG = 65）或实验组（EG = 65），实验组接受基于有氧训练和抗阻训练相结合的为期24个月的监督体育活动计划。通过将参与者服用的所有降压药物的规定日剂量（PDD）与限定日剂量（DDD）的比值相加，确定每个参与者的降压药物负荷。在0、6、12、18和24个月时评估结果指标。
共有76名参与者完成了24个月的评估，重复测量方差分析显示，与对照组相比，实验组在18个月（P < 0.017）和24个月（P < 0.003）时的降压药物负荷显著更低。
长期体育活动计划可降低老年原发性高血压患者的降压药物负荷。实验组药物负荷摄入量的改善趋势和对照组药物负荷增加的趋势，尽管随时间推移不显著，但导致两组在18个月时存在显著差异，在24个月时差异更大。这一趋势证明了体育活动对衰老过程及其相关健康风险因素具有保护作用。
