di Cagno Alessandra, Buonsenso Andrea, Centorbi Marco, Manni Luigi, Di Costanzo Alfonso, Casazza Giusy, Parisi Attilio, Guerra Germano, Calcagno Giuseppe, Iuliano Enzo, Soligo Marzia, Fiorilli Giovanni
Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
Front Aging Neurosci. 2023 Feb 9;15:1086487. doi: 10.3389/fnagi.2023.1086487. eCollection 2023.
Whole-body electromyostimulation (WB-EMS) was never previously applied to Parkinson's disease (PD) patients. This randomized controlled study aimed to find the most effective and safe WB-EMS training protocol for this population.
Twenty-four subjects (age: 72.13 ± 6.20 years), were randomly assigned to three groups: a high-frequency WB-EMS strength training group (HFG) (rectangular stimulation at 85 Hz, 350 μs, 4 s stimulation/4 s rest), a low-frequency WB-EMS aerobic training group (LFG) (rectangular stimulation 7 Hz, 350 μs, with a continuous pulse duration), and an inactive control group (CG). Participants of the two experimental groups underwent 24 controlled WB-EMS training sessions, with a duration of 20 min each, during 12-week intervention. Serum growth factors (BDNF, FGF-21, NGF and proNGF), α-synuclein, physical performance and Parkinson's Disease Fatigue Scale (PFS-16) responses were analyzed to evaluate the pre-post variation and differences among groups.
Significant interactions of TimeGroups were detected for BDNF (TimeGroups = 0.024; TimeCG, = -628, IC95% = -1,082/-174, = 0.008), FGF-21 (TimeGroups = 0.009; TimeLFG = 1,346, IC95% = 423/2268, = 0.005), and α-synuclein (TimeGroups = 0.019; Time*LFG = -1,572, IC95% = -2,952/-192, = 0.026). analyses and comparisons of ΔS (post-pre), performed independently for each group, showed that LFG increased serum BDNF levels (+ 203 pg/ml) and decreased α-synuclein levels (-1,703 pg/ml), while HFG showed the opposite effects (BDNF: -500 pg/ml; α-synuclein: + 1,413 pg/ml). CG showed a significant BDNF reduction over time. Both LFG and HFG showed significant improvements in several physical performance outcomes and the LFG showed better results than HFG. Concerning PFS-16, significant differences over time ( = -0.4, IC95% = -0.8/-0.0, = 0.046) and among groups (among all groups < 0.001) were found, and the LFG exhibited better results than the HFG ( = -1.0, IC95% = -1.3/-0.7, < 0.001), and CG ( = -1.7, IC95% = -2.0/-1.4, < 0.001) with this last one that worsened over time.
LFG training was the best choice for improving or maintaining physical performance, fatigue perception and variation in serum biomarkers.
https://www.clinicaltrials.gov/ct2/show/NCT04878679, identifier NCT04878679.
全身肌电刺激（WB-EMS）此前从未应用于帕金森病（PD）患者。这项随机对照研究旨在为该人群找到最有效且安全的WB-EMS训练方案。
24名受试者（年龄：72.13±6.20岁）被随机分为三组：高频WB-EMS力量训练组（HFG）（85Hz、350μs的矩形刺激，4秒刺激/4秒休息）、低频WB-EMS有氧训练组（LFG）（7Hz、350μs的矩形刺激，连续脉冲持续时间）和非活动对照组（CG）。两个实验组的参与者在12周的干预期间接受了24次可控的WB-EMS训练，每次持续20分钟。分析血清生长因子（BDNF、FGF-21、NGF和proNGF）、α-突触核蛋白、身体机能以及帕金森病疲劳量表（PFS-16）的反应，以评估组内前后变化及组间差异。
检测到BDNF（时间组 = 0.024；时间CG = -628，IC95% = -1,082/-174， = 0.008）、FGF-21（时间组 = 0.009；时间LFG = 1,346，IC95% = 423/（此处原文有误，应为2268）， = 0.005）和α-突触核蛋白（时间组 = 0.019；时间LFG = -1,572，IC95% = -2,952/-192， = 0.026）存在显著的时间*组交互作用。对每组独立进行的ΔS（后-前）分析和比较表明，LFG组血清BDNF水平升高（+203pg/ml）且α-突触核蛋白水平降低（-1,703pg/ml），而HFG组则呈现相反效果（BDNF：-500pg/ml；α-突触核蛋白：+1,413pg/ml）。CG组随时间推移BDNF显著降低。LFG组和HFG组在多项身体机能指标上均有显著改善，且LFG组效果优于HFG组。关于PFS-16，发现随时间有显著差异（ = -0.4，IC95% = -0.8/-0.0， = 0.046）以及组间有显著差异（所有组间 < 0.001），LFG组效果优于HFG组（ = -1.0，IC95% = -1.3/-0.7， < 0.001）和CG组（ = -1.7，IC95% = -2.0/-1.4， < 0.001），CG组随时间推移情况恶化。
LFG训练是改善或维持身体机能、疲劳感知及血清生物标志物变化的最佳选择。
https://www.clinicaltrials.gov/ct2/show/NCT04878679，标识符NCT04878679。
