Majid Abdul, Hassan Fasilat Oluwakemi, Hoque Md Monirul, Gbadegoye Joy Olaoluwa, Lebeche Djamel
Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Translational Research Building, Room 318H, 71 S. Manassas, Memphis, TN 38163, USA.
College of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
J Cardiovasc Dev Dis. 2023 Jul 21;10(7):313. doi: 10.3390/jcdd10070313.
Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure. Despite significant research efforts in characterizing and identifying key molecular mechanisms associated with myocardial fibrosis, effective treatment for this condition is still out of sight. In this regard, bioactive compounds have emerged as potential therapeutic antifibrotic agents due to their anti-inflammatory and antioxidant properties. These compounds exhibit the ability to modulate fibrogenic processes by inhibiting the production of extracellular matrix proteins involved in fibroblast to myofibroblast differentiation, or by promoting their breakdown. Extensive investigation of these bioactive compounds offers new possibilities for preventing or reducing cardiac fibrosis and its detrimental consequences. This comprehensive review aims to provide a thorough overview of the mechanisms underlying cardiac fibrosis, address the limitations of current treatment strategies, and specifically explore the potential of bioactive compounds as therapeutic interventions for the treatment and/or prevention of cardiac fibrosis.
心脏纤维化是一种病理状态，其特征是心脏中胶原蛋白和其他细胞外基质成分过度沉积。它被认为是心力衰竭发生和进展的主要促成因素。尽管在表征和识别与心肌纤维化相关的关键分子机制方面进行了大量研究，但针对这种病症的有效治疗仍然遥不可及。在这方面，生物活性化合物因其抗炎和抗氧化特性而成为潜在的治疗性抗纤维化药物。这些化合物能够通过抑制参与成纤维细胞向肌成纤维细胞分化的细胞外基质蛋白的产生，或通过促进其分解来调节纤维化过程。对这些生物活性化合物的广泛研究为预防或减少心脏纤维化及其有害后果提供了新的可能性。这篇综述旨在全面概述心脏纤维化的潜在机制，阐述当前治疗策略的局限性，并特别探讨生物活性化合物作为治疗和/或预防心脏纤维化的治疗干预措施的潜力。
