Klemm K, Börner M
Unfallchirurgie. 1986 Jun;12(3):128-31. doi: 10.1007/BF02588392.
In the treatment of chronic osteomyelitis radical removal of sequestrated bone fragments is of essential importance. Any antibiotic therapy - whether systemically or locally applied - can only be a supplementary measure. By implantation of gentamicin-PMMA-chains into infected cavities high local concentrations of the antibiotic can be achieved which are far above the minimal bactericidal concentrations of most common pathogens. As result of the very low concentrations of gentamicin in the serum and urine there is no hazard of nephrotoxicity and ototoxicity. Chronic sequestrating osteosyntheses and infected non-unions are the most important indications for the application of gentamicin-PMMA-chains.
在慢性骨髓炎的治疗中，彻底清除死骨碎片至关重要。任何抗生素治疗——无论是全身应用还是局部应用——都只能作为辅助措施。通过将庆大霉素-聚甲基丙烯酸甲酯链植入感染腔，可以实现抗生素的高局部浓度，这远远高于大多数常见病原体的最低杀菌浓度。由于血清和尿液中庆大霉素的浓度极低，不存在肾毒性和耳毒性风险。慢性骨桥接骨合成和感染性骨不连是应用庆大霉素-聚甲基丙烯酸甲酯链的最重要指征。
