Marcinko D E
J Foot Surg. 1985 Mar-Apr;24(2):116-21.
The local implantation of gentamicin-impregnated polymethylmethacrylate beads, in conjunction with the application of consistent surgical principles, has been used in Europe for the past decade. The system has proved successful in the treatment of osteomyelitis and soft tissue infections. It combines the benefits of high local antibiotic tissue levels with the achievement of primary wound closure. In this presentation, the advantages, disadvantages, and technical application of this new drug delivery system is introduced to the profession for consideration and future use.
在过去十年中,庆大霉素浸渍的聚甲基丙烯酸甲酯珠粒的局部植入,结合一贯的外科手术原则,已在欧洲得到应用。该系统已被证明在治疗骨髓炎和软组织感染方面是成功的。它将高局部抗生素组织水平的益处与实现一期伤口闭合相结合。在本报告中,将这种新的药物递送系统的优点、缺点和技术应用介绍给同行,以供考虑和未来使用。