Qvist N, Nielsen K K, Kristensen E S, Ehlers D, Jensen K M, Krarup T, Christoffersen J
Urol Int. 1986;41(3):199-201. doi: 10.1159/000281197.
Of 41 children, aged 5-15 years, referred consecutively because of recurrent urinary tract infections (UTIs) and/or enuresis, 18 (44%) showed detrusor instability (DI) in at least 2 of 6 CO2 cystometries. One child was excluded from the study because of lack of follow-up. Four children with less pronounced DI (instability during less than or equal to 50% of the cystometries performed) and frequent UTIs were given antibiotics prophylactically for 3 months. In the remaining 13 children, DI was found during more than half the cystometries performed, and 11 of these children, who also had urge incontinence, were treated with emepronium bromide, 400-600 mg daily (10-12 mg/kg) for 3 months. In 7 of the patients this treatment was supplemented by antibiotics prophylactically because of frequent UTIs. Two children with special problems received other types of treatment. All children were free from symptoms at a clinical check-up 6 months later, 95% confidence limits 0-20%.
在因复发性尿路感染（UTIs）和/或遗尿症而连续转诊的41名5至15岁儿童中，18名（44%）在6次二氧化碳膀胱测压中的至少2次显示逼尿肌不稳定（DI）。一名儿童因缺乏随访而被排除在研究之外。4名DI不太明显（在进行的膀胱测压中不稳定时间小于或等于50%）且频繁发生UTIs的儿童接受了3个月的预防性抗生素治疗。在其余13名儿童中，在超过一半的膀胱测压中发现了DI，其中11名也有急迫性尿失禁的儿童接受了溴化依米普明治疗，每天400 - 600毫克（10 - 12毫克/千克），持续3个月。在7名患者中，由于频繁发生UTIs，这种治疗辅以预防性抗生素。两名有特殊问题的儿童接受了其他类型的治疗。6个月后的临床检查中，所有儿童均无症状，95%置信区间为0 - 20%。
