Central Clinical School, Department of Psychiatry, Monash University, Victoria, Australia; Statewide Progressive Neurological Disease Service, Calvary Health Care Bethlehem, Victoria, Australia.
Central Clinical School, Department of Psychiatry, Monash University, Victoria, Australia; Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Victoria, Australia.
Clin Neurophysiol. 2023 Sep;153:166-176. doi: 10.1016/j.clinph.2023.06.021. Epub 2023 Jul 14.
To find sensitive neurophysiological correlates of non-motor symptoms in Huntington's disease (HD), which are essential for the development and assessment of novel treatments.
We used resting state EEG to examine differences in oscillatory activity (analysing the isolated periodic as well as the complete EEG signal) and functional connectivity in 22 late premanifest and early stage people with HD and 20 neurotypical controls. We then assessed the correlations between these neurophysiological markers and clinical measures of apathy and processing speed.
Significantly lower theta and greater delta resting state power was seen in the HD group, as well as significantly greater delta connectivity. There was a significant positive correlation between theta power and processing speed, however there were no associations between the neurophysiological and apathy measures.
We speculate that these changes in oscillatory power and connectivity reflect ongoing, frontally concentrated degenerative and compensatory processes associated with HD.
Our findings support the potential utility of quantitative EEG as a proximate marker of processing speed, but not apathy in HD.
寻找亨廷顿病（HD）非运动症状的敏感神经生理相关性，这对于新型治疗方法的开发和评估至关重要。
我们使用静息态 EEG 检查 22 名晚前期和早期 HD 患者和 20 名神经典型对照组之间的振荡活动（分析孤立的周期性和完整的 EEG 信号）和功能连接的差异。然后，我们评估了这些神经生理标志物与淡漠和处理速度的临床测量之间的相关性。
HD 组的静息状态下θ波和δ波功率明显降低，δ波连接明显增加。θ波功率与处理速度呈显著正相关，但神经生理和淡漠测量之间没有关联。
我们推测，这些振荡功率和连接的变化反映了与 HD 相关的持续的、集中在前额的退行性和代偿性过程。
我们的发现支持定量 EEG 作为 HD 中处理速度而不是淡漠的近似标志物的潜在效用。
