Han Joan, Pontikes Theodote K, Zabinski Jeffrey, Gilbert Cyrus, Hicks Christian, Fayez Rola, Walterfang Mark, Mahdanian Artin, Nanavati Julie, Lobner Katie, Leppla Idris, Roy Durga
Department of Psychiatry, Johns Hopkins, Baltimore, MD.
Department of Psychiatry, Loyola University Medical Center, Maywood, IL.
J Acad Consult Liaison Psychiatry. 2023 Nov-Dec;64(6):533-549. doi: 10.1016/j.jaclp.2023.07.002. Epub 2023 Jul 27.
The COVID-19 pandemic has been an inciting factor for a wide variety of neuropsychiatric symptoms, including first-episode psychosis (FEP).
The aim of this systematic review was to summarize the current literature on COVID-19 associated postviral FEP.
A systematic review was completed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and identified 81 articles that met inclusion criteria.
Articles included case reports, case series, and cohort studies with postviral FEP occurring outside the setting of delirium, demonstrating a broad range of symptoms.
This systematic review shows that postviral FEP associated with COVID-19 follows a pattern similar to psychosis associated with other viral infections and is an important consideration when building a differential for FEP when delirium has been ruled out. Better understanding of postviral FEP associated with COVID-19 and other viral illnesses may help clarify aspects of underlying pathophysiology of psychotic symptoms broadly.
新冠疫情一直是引发多种神经精神症状的诱因，包括首发精神病（FEP）。
本系统评价的目的是总结当前关于新冠病毒感染后FEP的文献。
按照系统评价和Meta分析的首选报告项目指南完成了一项系统评价，确定了81篇符合纳入标准的文章。
文章包括病例报告、病例系列和队列研究，其中病毒感染后FEP发生在谵妄之外，表现出广泛的症状。
本系统评价表明，与新冠病毒感染相关的病毒感染后FEP与其他病毒感染相关的精神病遵循相似模式，在排除谵妄后对FEP进行鉴别诊断时是一个重要考虑因素。更好地了解与新冠病毒感染及其他病毒疾病相关的病毒感染后FEP，可能有助于广泛阐明精神病性症状潜在病理生理学的各个方面。
