School of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Guiyang Hospital of Stomatology, Guiyang, Guizhou, China.
J Bone Miner Metab. 2023 Sep;41(5):673-681. doi: 10.1007/s00774-023-01443-w. Epub 2023 Jul 28.
Observational studies demonstrated that the relationship between bone mineral density and oral diseases is mixed. To access the association between heel bone mineral density and various oral diseases, we conducted the Mendelian randomization analysis to explore the association.
Two-sample bidirectional Mendelian analysis was used to explore the relationship between heel bone mineral density and various oral diseases. The inverse-variance weighted (IVW) was used as the primary effect estimate, and various methods were applied to test the reliability and stability of the results, namely MR-Egger, weighted median, simple mode, and weighted mode.
This study showed that there was a negative relationship between heel BMD and periodontitis when heel BMD was used as an exposure factor and periodontitis as an outcome factor (IVW OR = 0.85; 95% CI, 0.75-0.95; p = 0.005). Bidirectional Mendelian randomization showed that there was no statistically significant association between periodontitis and heel bone mineral density when chronic periodontitis was the exposure factor (p > 0.05). And there was no significant relationship between heel bone mineral density and other oral diseases (dental caries, diseases of pulp and periapical tissues, impacted teeth, cleft lip, and cleft palate, oral and oropharyngeal cancer) (p > 0.05).
This study showed that there was a negative relationship between heel bone density and periodontitis, and the decrease in heel bone density could promote the occurrence of periodontitis. In addition, there was no statistically significant relationship between heel bone density and other oral diseases.
观察性研究表明，骨密度与口腔疾病之间的关系是混杂的。为了评估跟骨骨密度与各种口腔疾病之间的关联，我们进行了孟德尔随机化分析以探索这种关联。
采用两样本双向孟德尔分析来探讨跟骨骨密度与各种口腔疾病之间的关系。使用逆方差加权（IVW）作为主要效应估计，并应用各种方法来检验结果的可靠性和稳定性，包括 MR-Egger、加权中位数、简单模式和加权模式。
本研究表明，当以跟骨骨密度作为暴露因素，牙周炎作为结局因素时，跟骨 BMD 与牙周炎呈负相关（IVW OR = 0.85；95%CI，0.75-0.95；p = 0.005）。双向孟德尔随机化分析表明，当慢性牙周炎为暴露因素时，牙周炎与跟骨骨密度之间没有统计学上的显著关联（p > 0.05）。并且，跟骨骨密度与其他口腔疾病（龋齿、牙髓和根尖周组织疾病、阻生牙、唇裂和腭裂、口腔和口咽癌）之间也没有显著的关系（p > 0.05）。
本研究表明，跟骨密度与牙周炎之间呈负相关，跟骨密度的降低可能会促进牙周炎的发生。此外，跟骨密度与其他口腔疾病之间没有统计学上的显著关系。
