Guerrini V H, English P B, Filippich L J, Schneider J, Bourne D W
Vet Rec. 1986 Jul 26;119(4):81-3. doi: 10.1136/vr.119.4.81.
Each of five dogs was given cefotaxime at a dose rate of 50 mg/kg by intravenous, intramuscular and subcutaneous routes, in three separate treatments. Plasma concentration time profiles were characterised by a linear two-compartment model after the intravenous administration. After intravenous, intramuscular and subcutaneous injections the mean biological half-lives were 0.74, 0.83 and 1.71 hours, respectively. The apparent steady state volume of distribution was 0.48 litre/kg and body clearance after intravenous injection was approximately 0.63 litre/hour/kg. After intramuscular and subcutaneous injections peak plasma cefotaxime concentrations were 47 +/- 15 and 29.6 +/- 16 micrograms/ml at 0.5 and 0.8 hours, respectively. The average bioavailability of cefotaxime given by intramuscular injection was 86.5 per cent and for cefotaxime given subcutaneously it was approximately 100 per cent. After two hours, the cefotaxime plasma concentration remained higher after subcutaneous than after intramuscular administration.
五只狗分别接受了三次不同的治疗，通过静脉、肌肉和皮下途径以50毫克/千克的剂量率给予头孢噻肟。静脉给药后，血浆浓度-时间曲线由线性二室模型表征。静脉注射、肌肉注射和皮下注射后的平均生物半衰期分别为0.74小时、0.83小时和1.71小时。表观稳态分布容积为0.48升/千克，静脉注射后的机体清除率约为0.63升/小时/千克。肌肉注射和皮下注射后，头孢噻肟的血浆峰值浓度分别在0.5小时和0.8小时达到47±15微克/毫升和29.6±16微克/毫升。肌肉注射头孢噻肟的平均生物利用度为86.5%，皮下注射头孢噻肟的生物利用度约为100%。两小时后，皮下给药后的头孢噻肟血浆浓度仍高于肌肉给药后的浓度。
