Liu Xiaobo, Lu Minming, Guo Xiangli, Xu Huajian, Xu Jun
School of Food and Biological Engineering, Anhui Province Key Laboratory of, Advance Catalytic Materials and Reaction Engineering, Hefei University of Technology, Hefei, 230009, P. R. China.
Chemistry. 2023 Oct 13;29(57):e202302041. doi: 10.1002/chem.202302041. Epub 2023 Sep 11.
A novel visible-light photoredox strategy is reported for the efficient dehydroxylative alkylation of a wide array of α-hydroxy carboxylic acid derivatives using diaryl boron radical. The reaction features readily accessible starting materials, broad substrate scope with excellent functionality tolerance. Preliminary mechanistic studies reveal that the spin-center shift process is responsible for the C-O bond activation, which is promoted by the diaryl boron radical generated from bench-stable and commercially available tetraphenyl borate (NaBPh ).
报道了一种新型可见光光氧化还原策略，该策略使用二芳基硼自由基对多种α-羟基羧酸衍生物进行高效的脱羟基烷基化反应。该反应的特点是起始原料易于获得，底物范围广泛，对官能团具有出色的耐受性。初步机理研究表明，自旋中心转移过程是C-O键活化的原因，该过程由稳定且市售的四苯基硼酸钠（NaBPh）产生的二芳基硼自由基促进。
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