14C-地考喹酯在鸡、鹌鹑和绵羊体内的代谢比较

Comparative metabolism of 14C-decoquinate in chickens, quail and sheep.

作者信息

Seman D H, Hayek M G, Batson D B, Cantor A H, Tucker R E, Muntifering R B, Ely D G, Soler B L, Mitchell G E

出版信息

Vet Hum Toxicol. 1986 Aug;28(4):325-7.

Abstract

Removal of pulse doses of 14C-decoquinate from blood was studied in chicken hens, quail hens, and ewe lambs. Estimated clearance before the first post-injection sample at 1 1/2 hr was 96% for sheep, 99% for chickens and over 99% for quail. Half-times for removal of the remaining radioactivity from the blood were 26.8 hr for sheep, 144.7 hr for chickens and 27.2 hr for quail. Treating the chicken data as biphasic yielded a 3.4 hr half-time for an initial fast phase and 210 hr for a later slow phase. Radioactivity disappeared from sheep blood between 2 and 7 d, from chicken blood between 7 and 14 d, and from quail blood between 1 and 2 d. Urine accounted for 35% of the radioactivity administered to sheep. It did not contain detectable activity after the third day.

摘要

在母鸡、鹌鹑母禽和羔羊中研究了从血液中清除脉冲剂量的14C-地考喹酯的情况。绵羊在注射后1.5小时采集的首个样本之前的估计清除率为96%，鸡为99%，鹌鹑超过99%。绵羊血液中剩余放射性物质清除的半衰期为26.8小时，鸡为144.7小时，鹌鹑为27.2小时。将鸡的数据视为双相，初始快速相的半衰期为3.4小时，后期缓慢相的半衰期为210小时。放射性物质在2至7天从绵羊血液中消失，7至14天从鸡血液中消失，1至2天从鹌鹑血液中消失。尿液占给予绵羊放射性物质的35%。第三天后尿液中未检测到放射性。