Li Shiyu, Lin Ji, Tao Siyuan, Guo Linwen, Huang Wenzhi, Li Jingwen, Du Chunping, Wang Zhiting, Liu Liwen, Chen Yi, Qiao Fu
Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Infection Control, West China Hospital, Sichuan University, Chengdu 610041, China.
Antibiotics (Basel). 2023 Jul 18;12(7):1199. doi: 10.3390/antibiotics12071199.
To assess the effectiveness of multi-model strategies on healthcare-associated infections (HAIs) caused by multi-drug resistant organisms (MDROs) in rehabilitation units. A semi-experimental study was conducted in a rehabilitation unit with 181 beds from January 2021 to December 2022 in a teaching hospital with 4300 beds in China. In 2021, many basic prevention and control measures were conducted routinely. Based on the basic measures, strengthening multi-model strategies for the prevention and control of MDROs was pursued year-round since 1 January 2022. A total of 6206 patients were enrolled during the study period. The incidence density of HAIs caused by MDROs decreased from 1.22 (95% CI, 0.961.54) cases/1000 patient-days in the pre-intervention period to 0.70 (95% CI, 0.500.95) cases/1000 patient-days ( = 0.004). Similarly, the incidence of HAIs in the intervention period was 50.85% lower than that in the pre-intervention period (2.02 (95% CI, 1.50~2.72) vs. 4.11 (95% CI, 3.45-4.85) cases/100 patients, < 0.001). The rate of MDROs isolated from the environment decreased by 30.00%, although the difference was not statistically significant ( = 0.259). Multi-model strategies can reduce the incidence of HAIs and HAIs caused by certain MDROs in the rehabilitation unit.
评估多模式策略对康复病房中多重耐药菌（MDROs）引起的医疗相关感染（HAIs）的有效性。在中国一家拥有4300张床位的教学医院中，于2021年1月至2022年12月在一个拥有181张床位的康复病房进行了一项半实验性研究。2021年，常规开展了许多基本防控措施。自2022年1月1日起，在基本措施的基础上，全年推行强化多重耐药菌防控的多模式策略。研究期间共纳入6206例患者。多重耐药菌引起的医疗相关感染的发病密度从干预前期的1.22（95%CI，0.961.54）例/1000患者日降至0.70（95%CI，0.500.95）例/1000患者日（P = 0.004）。同样，干预期的医疗相关感染发病率比干预前期低50.85%（2.02（95%CI，1.50~2.72）对4.11（95%CI，3.45 - 4.85）例/100患者，P < 0.001）。从环境中分离出的多重耐药菌比例下降了30.00%，尽管差异无统计学意义（P = 0.259）。多模式策略可降低康复病房中医疗相关感染以及由某些多重耐药菌引起的医疗相关感染的发病率。
