Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA.
Cells. 2023 Jul 18;12(14):1879. doi: 10.3390/cells12141879.
Liver cancer is a global health challenge as it is the third leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is often found in liver cells, where it is associated with high morbidity and mortality rates. Recent studies have shown that extracellular vesicles (EVs) secreted by HCC cells play a critical role in HCC progression and metastasis. EVs contain proteins, nucleic acids, lipids, and metabolites as cargos. EVs derived from HCC cells can transfer oncogenic factors to surrounding cells leading to increased tumor growth, cell invasion, and angiogenesis. In this review, we summarize the roles that EVs play and the specific effects of their cargos on HCC progression and metastasis and identify potential therapeutic targets for HCC treatment.
肝癌是全球健康挑战，因为它是全球癌症死亡的第三大主要原因。肝细胞癌 (HCC) 是最常见的肝癌类型，通常发生在肝细胞中，与高发病率和死亡率相关。最近的研究表明，肝癌细胞分泌的细胞外囊泡 (EVs) 在 HCC 进展和转移中发挥关键作用。EVs 包含蛋白质、核酸、脂质和代谢物等 cargo。源自 HCC 细胞的 EVs 可以将致癌因子传递给周围细胞，导致肿瘤生长、细胞侵袭和血管生成增加。在这篇综述中，我们总结了 EVs 的作用以及其 cargo 对 HCC 进展和转移的具体影响，并确定了 HCC 治疗的潜在治疗靶点。
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