Anastasiadis Xristos, Matsas Alkis, Panoskaltsis Theodoros, Bakas Panagiotis, Papadimitriou Dimitrios T, Christopoulos Panagiotis
Second Department of Obstetrics and Gynecology, "Aretaieion" Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Children (Basel). 2023 Jul 17;10(7):1234. doi: 10.3390/children10071234.
A growing body of evidence suggests that chemicals interfere with the age of onset of menarche. We conducted a review in order to demonstrate the relationship between several categories of chemicals and menarche. We searched for English language papers using the Medline/PubMed database until April 2023. The chemical factors found to affect menarche were prenatal and antenatal smoke, phthalates, phenols, organochlorines, perfluoroalkyls and polyfluoroalkyls, metals, air pollutants and polybrominated diphenyl ethers. Low or high exposure to each chemical compound could affect the age of menarche, leading to early or delayed menarche. Furthermore, the results show that intrauterine exposure may have a different impact from antenatal exposure. There is evidence that endocrine-disrupting chemicals affect the age of menarche, but more research needs to be conducted.
越来越多的证据表明，化学物质会干扰月经初潮的起始年龄。我们进行了一项综述，以证明几类化学物质与月经初潮之间的关系。我们使用Medline/PubMed数据库搜索截至2023年4月的英文论文。发现影响月经初潮的化学因素有产前和产后吸烟、邻苯二甲酸盐、酚类、有机氯、全氟烷基和多氟烷基、金属、空气污染物以及多溴二苯醚。每种化合物的低暴露或高暴露都可能影响月经初潮的年龄，导致月经初潮提前或推迟。此外，结果表明宫内暴露可能与产前暴露有不同的影响。有证据表明，内分泌干扰化学物质会影响月经初潮的年龄，但还需要进行更多的研究。
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