Park One, Park Jong-Tae, Chi Youngchan, Kwak Kyeongmin
Department of Occupational and Environmental Medicine, Korea University Ansan Hospital, Ansan, Korea.
Department of Environmental Health Sciences, Seoul National University Graduate School of Public Health, Seoul, Korea.
Ann Occup Environ Med. 2021 Feb 1;33:e4. doi: 10.35371/aoem.2021.33.e4. eCollection 2021.
Phthalates are one of renowned endocrine-disrupting chemicals, although inconsistent results are present around their effect on onset of menarche. Our hypothesis is that pre-pubertal exposure to phthalates is associated with acceleration of menarche.
We analyzed a total of 236 middle school (7th to 9th grade) girls from Korean National Environmental Health Survey 20152017. We used multiple linear regression to investigate impact of eight phthalate metabolites on age of menarche. We also conducted logistic regression to evaluate association between phthalate metabolite concentrations and early onset of menarche, adjusting for grade, maternal age of menarche and body mass index (BMI).
In linear regression analysis, no significant association was found for any phthalate metabolites. In logistic regression analysis, however, odds ratios (ORs) of early menarche were significantly increased for mono-n-butyl phthalate (MnBP) and for sum of all phthalates. When compared to group with the lowest level, high concentration group for MnBP presented significantly increased odds of early menarche (OR: 2.09; 95% confidence interval [CI]: 1.03, 4.23) after adjusting for grade, maternal age of menarche and BMI. Furthermore, high concentrations of sum of all phthalates were associated with significant increase of OR of early menarche (OR: 2.22; 95% CI: 1.10, 4.49) after adjustment, compared to the lowest concentration group.
Results of our study suggest that exposure to phthalates around puberty may be associated with increased risk of early menarche.
邻苯二甲酸盐是著名的内分泌干扰化学物质之一，尽管关于其对初潮影响的研究结果并不一致。我们的假设是青春期前接触邻苯二甲酸盐与初潮提前有关。
我们分析了来自2015 - 2017年韩国国家环境卫生调查的236名初中（7至9年级）女生的数据。我们使用多元线性回归研究8种邻苯二甲酸酯代谢物对初潮年龄的影响。我们还进行了逻辑回归，以评估邻苯二甲酸酯代谢物浓度与初潮提前之间的关联，并对年级、母亲初潮年龄和体重指数（BMI）进行了调整。
在线性回归分析中，未发现任何邻苯二甲酸酯代谢物有显著关联。然而，在逻辑回归分析中，邻苯二甲酸单丁酯（MnBP）和所有邻苯二甲酸酯总和的初潮提前优势比（OR）显著增加。与最低水平组相比，在调整了年级、母亲初潮年龄和BMI后，MnBP高浓度组初潮提前的几率显著增加（OR：2.09；95%置信区间[CI]：1.03，4.23）。此外，与最低浓度组相比，调整后所有邻苯二甲酸酯总和的高浓度与初潮提前的OR显著增加相关（OR：2.22；95% CI：1.10，4.49）。
我们的研究结果表明，青春期前后接触邻苯二甲酸盐可能与初潮提前风险增加有关。
