Gu Shuangshuang, Wang Shuo, Wang Yuwen, Zhang Juan, Cai Hong, Zou Runmei, Wang Cheng
Department of Pediatric Cardiovasology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Children (Basel). 2023 Jul 19;10(7):1244. doi: 10.3390/children10071244.
(1) Objective: In this research, we explored the difference in blood pressure variability (BPV) between children with postural tachycardia syndrome (POTS) and healthy children. Furthermore, we tried to investigate the effect of BPV on POTS and its relationship with prognosis of POTS. (2) Methods: 47 children with POTS (11.2 ± 1.8 years, 23 males) were enrolled in the POTS group and 30 healthy children (10.9 ± 1.9 years, 15 males) were matched for the control group. All participants completed 24 h ambulatory blood pressure monitoring (24hABPM). Thirty-three children with POTS were followed up for 52.0 (30.5, 90.5) days and were divided into a response group and a non-response group after evaluation. (3) Results: The 24 h diastolic blood pressure standard deviation (24hDSD), daytime diastolic blood pressure standard deviation (DDSD), nighttime systolic blood pressure standard deviation (NSSD), daytime diastolic blood pressure variation coefficient (DDCV) and nighttime systolic blood pressure variation coefficient (NSCV) in the control group were lower than those in the POTS group ( < 0.05). Percentage of females, age and height were lower in the response group than in the non-response group in children with POTS ( < 0.05). Univariate analysis showed that 24hDSD, DDSD, NSSD, DDCV and NSCV were potential risk factors for POTS, and sex and height were potential risk factors for poor prognosis of POTS. After adjusting for covariates, the risk of POTS increased by 48%, 53% and 49% when DDSD, NSSD and NSCV increased by 1 mmHg, 1 mmHg and 1%, respectively. The risk of poor prognosis in females was 12.99 times higher than that in males. (4) Conclusions: The results suggest that children with POTS may have an abnormal circadian rhythm in blood pressure and increased BPV. DDSD, NSSD and NSCV are independent risk factors for POTS, and being female is an independent risk factor for poor prognosis of POTS.
(1) 目的：本研究探讨体位性心动过速综合征（POTS）患儿与健康儿童血压变异性（BPV）的差异。此外，我们试图研究BPV对POTS的影响及其与POTS预后的关系。(2) 方法：将47例POTS患儿（11.2±1.8岁，男23例）纳入POTS组，选取30例健康儿童（10.9±1.9岁，男15例）作为对照组。所有参与者均完成24小时动态血压监测（24hABPM）。对33例POTS患儿进行了52.0（30.5，90.5）天的随访，评估后分为反应组和无反应组。(3) 结果：对照组的24小时舒张压标准差（24hDSD）、日间舒张压标准差（DDSD）、夜间收缩压标准差（NSSD）、日间舒张压变异系数（DDCV）和夜间收缩压变异系数（NSCV）均低于POTS组（P<0.05）。POTS患儿中，反应组的女性比例、年龄和身高均低于无反应组（P<0.05）。单因素分析显示，24hDSD、DDSD、NSSD、DDCV和NSCV是POTS的潜在危险因素，性别和身高是POTS预后不良的潜在危险因素。校正协变量后，当DDSD、NSSD和NSCV分别升高1 mmHg、1 mmHg和1%时，POTS风险分别增加48%、53%和49%。女性预后不良的风险是男性的12.99倍。(4) 结论：结果表明，POTS患儿可能存在血压昼夜节律异常及BPV升高。DDSD、NSSD和NSCV是POTS的独立危险因素，女性是POTS预后不良的独立危险因素。
