Fan Leon, Hu Ellen Y, Hey Grace E, Hu Wei
Computer Science and Molecular Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
The International Baccalaureate Program, Tampa, FL 33610, USA.
Brain Sci. 2023 Jun 25;13(7):993. doi: 10.3390/brainsci13070993.
Parkinson's disease (PD) is a progressive central nervous system disease with a common motor symptom of gait disturbance in PD, which is more pronounced in the later stages. Although FDA-approved treatments, including dopaminergic pharmacotherapy, deep brain stimulation, and rehabilitation, have some benefits in improving gait dysfunction, a fair amount of advanced PD patients can develop a disability, social isolation, and high mortality and morbidity. Recently, clinicians and scientists have applied music to clinical therapy, namely music therapy. It has been used as a unique rehabilitation tool to improve PD-induced gait and speech disorders. Based on relevant studies in recent years, this paper reviews the published literature about music in treating gait disorders and speech problems in PD patients. Additionally, we discuss current studies' limitations and emphasize the future potential research fields.
帕金森病(PD)是一种进行性中枢神经系统疾病,PD常见的运动症状是步态障碍,在疾病后期更为明显。尽管美国食品药品监督管理局(FDA)批准的治疗方法,包括多巴胺能药物治疗、深部脑刺激和康复治疗,在改善步态功能障碍方面有一定益处,但相当一部分晚期PD患者会出现残疾、社会隔离以及高死亡率和发病率。最近,临床医生和科学家将音乐应用于临床治疗,即音乐疗法。它已被用作一种独特的康复工具,以改善PD引起的步态和言语障碍。基于近年来的相关研究,本文综述了已发表的关于音乐治疗PD患者步态障碍和言语问题的文献。此外,我们讨论了当前研究的局限性,并强调了未来潜在的研究领域。